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Titolo:
HENOCH-SCHONLEIN PURPURA AND MEMBRANOPROLIFERATIVE-LIKE GLOMERULONEPHRITIS
Autore:
ORFILA C; LEPERT JC; MODESTO A; PIPY B; SUC JM;
Indirizzi:
CHU RANGUEIL,INSERM CJG9107,1 AVE JEAN POULHES F-31054 TOULOUSE FRANCE CHU RANGUEIL,SERV NEPHROL F-31054 TOULOUSE FRANCE
Titolo Testata:
Nephron
fascicolo: 1, volume: 74, anno: 1996,
pagine: 209 - 213
SICI:
0028-2766(1996)74:1<209:HPAMG>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
SCHOENLEIN NEPHRITIS; CHILDREN;
Keywords:
HENOCH-SCHONLEIN PURPURA; MEMBRANOPROLIFERATIVE GLOMERULONEPHRITIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
16
Recensione:
Indirizzi per estratti:
Citazione:
C. Orfila et al., "HENOCH-SCHONLEIN PURPURA AND MEMBRANOPROLIFERATIVE-LIKE GLOMERULONEPHRITIS", Nephron, 74(1), 1996, pp. 209-213

Abstract

A 17-year-old man presented Henoch-Schonlein purpura with renal impairment, nephrotic syndrome needing transitory hemodialysis and hematuria. By light microscopy, the renal biopsy revealed membranoproliferative-like lesion associated with massive subendothelial deposits, some subepithelial deposits, hyalin thrombi and intracapillary neutrophils. By immunofluorescence, intense nodular and segmental deposits of IgG, IgM, IgA, C3, fibrinogen and Clq were found to be present in the intracapillary area and the mesangium. By electron microscopy, large subendothelial and rare subepithelial deposits were observed. A skin biopsy demonstrated leukocytoclastic skin vasculitis with IgA deposits in the arterial walls. Treatment with corticosteroids resulted in return renal to normal renal function but persistent proteinuria and hematuria. Asecond renal biopsy, performed after 2 months, showed a marked decrease in lesions and deposits. Fifteen months later, the patient presented normal serum creatinine level but proteinuria and hematuria persisted. At this time, a third renal biopsy was performed and showed segmental mesangial sclerosis and the decrease or disappearance of deposits. Two years after the first hospitalization, no abnormal serum creatinine or urinalysis were present. This report describes a detailed study of a case presented with Henoch-Schonlein purpura and morphologic features consistent with membranoproliferative-like lesion, who recovered normal renal function and urinalysis; repeat biopsies performed at intervals of 2 months and 1 year confirmed the disappearance of mesangial proliferation, double contours and deposits.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/12/20 alle ore 21:51:18