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Titolo:
THE TRANSCRIPTIONAL APPARATUS REQUIRED FOR MESSENGER-RNA ENCODING GENES IN THE YEAST SACCHAROMYCES-CEREVISIAE EMERGES FROM A JIGSAW PUZZLE OF TRANSCRIPTION FACTORS
Autore:
KUNZLER M; SPRINGER C; BRAUS GH;
Indirizzi:
UNIV ERLANGEN NURNBERG,INST MICROBIOL BIOCHEM & GENET,STAUDTSTR 5 D-91058 ERLANGEN GERMANY UNIV ERLANGEN NURNBERG,INST MICROBIOL BIOCHEM & GENET D-91058 ERLANGEN GERMANY UNIV GOTTINGEN,INST MICROBIOL D-37077 GOTTINGEN GERMANY
Titolo Testata:
FEMS microbiology reviews
fascicolo: 2, volume: 19, anno: 1996,
pagine: 117 - 136
SICI:
0168-6445(1996)19:2<117:TTARFM>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
RNA-POLYMERASE-II; TATA-BINDING PROTEIN; ACIDIC ACTIVATION DOMAINS; START-SITE SELECTION; C-TERMINAL DOMAIN; DNA-BINDING; CRYSTAL-STRUCTURE; IN-VIVO; 3-DIMENSIONAL STRUCTURE; SYNERGISTIC ACTIVATION;
Keywords:
PROMOTER; RNA POLYMERASE II HOLOENZYME; TRANSCRIPTION; YEAST;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
167
Recensione:
Indirizzi per estratti:
Citazione:
M. Kunzler et al., "THE TRANSCRIPTIONAL APPARATUS REQUIRED FOR MESSENGER-RNA ENCODING GENES IN THE YEAST SACCHAROMYCES-CEREVISIAE EMERGES FROM A JIGSAW PUZZLE OF TRANSCRIPTION FACTORS", FEMS microbiology reviews, 19(2), 1996, pp. 117-136

Abstract

The number of identified yeast factors involved in transcription has dramatically increased in recent years and the understanding of the interplay between the different factors has become more and more puzzling. Transcription initiation at the core promoter of mRNA encoding genes consisting of upstream, TATA and initiator elements requires an approximately ribosome-sized complex of more than 50 polypeptides. The recent identification and isolation of an RNA polymerase holoenzyme whichseems to be preassembled before interacting with a promoter allowed abetter understanding of the roles, assignments and interplays of the various constituents of the basal transcription machinery. Recruitmentof this complex to the promoter is achieved by numerous interactions with a variety of DNA-bound proteins. These interactions can be director mediated by additional adaptor proteins. Other proteins negativelyaffect transcription by interrupting the recruitment process through protein-protein or protein-DNA interactions. Some basic features of cis-acting elements, the transcriptional apparatus and various trans-acting factors involved in the initiation of mRNA synthesis in yeast are summarized.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/09/20 alle ore 17:22:26