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Titolo:
RECOMBINATION AND NONDISJUNCTION IN HUMANS AND FLIES
Autore:
KOEHLER KE; HAWLEY RS; SHERMAN S; HASSOLD T;
Indirizzi:
UNIV CALIF DAVIS,DEPT GENET,SECT MOL & CELLULAR BIOL DAVIS CA 95616 UNIV CALIF DAVIS,DEPT GENET,SECT MOL & CELLULAR BIOL DAVIS CA 95616 EMORY UNIV,SCH MED,DEPT GENET & MOL MED ATLANTA GA 30322 CASE WESTERN RESERVE UNIV,CTR HUMAN GENET CLEVELAND OH 44106 CASE WESTERN RESERVE UNIV,DEPT GENET CLEVELAND OH 44106 UNIV HOSP CLEVELAND CLEVELAND OH 44106
Titolo Testata:
Human molecular genetics
, volume: 5, anno: 1996,
pagine: 1495 - 1504
SICI:
0964-6906(1996)5:<1495:RANIHA>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
DROSOPHILA-MELANOGASTER; REDUCED RECOMBINATION; MATERNAL AGE; ABERRANT RECOMBINATION; METAPHASE ARREST; CELL-DIVISION; SEGREGATION; MECHANISMS; CHROMOSOME; MEIOSIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
52
Recensione:
Indirizzi per estratti:
Citazione:
K.E. Koehler et al., "RECOMBINATION AND NONDISJUNCTION IN HUMANS AND FLIES", Human molecular genetics, 5, 1996, pp. 1495-1504

Abstract

Recent studies of Drosophila and humans indicate that aberrant genetic recombination is an important component of nondisjunction in both species. In both, a proportion of nondisjunction is associated with failure to pair and/or recombine and in both, exchanges which are either too distal or too proximal increase the likelihood of malsegregation. In this review we provide two perspectives on these observations: first, a review of exchange and chromosome segregation in model organisms, focusing on Drosophila, and secondly an overview of nondisjunction in humans. This format allows us to describe the paradigms developed fromstudies of model organisms and to ask whether these paradigms apply to the human situation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 22:32:21