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Titolo:
INFLUENCE OF DIBUTYL PHTHALATE ON DERMAL SENSITIZATION TO FLUORESCEINISOTHIOCYANATE
Autore:
DEARMAN RJ; CUMBERBATCH M; HILTON J; CLOWES HM; FIELDING I; HEYLINGS JR; KIMBER I;
Indirizzi:
ICI PLC,CENT TOXICOL LAB,ALDERLEY PK MACCLESFIELD SK10 4TJ CHESHIRE ENGLAND
Titolo Testata:
Fundamental and applied toxicology
fascicolo: 1, volume: 33, anno: 1996,
pagine: 24 - 30
SICI:
0272-0590(1996)33:1<24:IODPOD>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
DRAINING LYMPH-NODES; CELLS; ABSORPTION; SKIN; MICE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
14
Recensione:
Indirizzi per estratti:
Citazione:
R.J. Dearman et al., "INFLUENCE OF DIBUTYL PHTHALATE ON DERMAL SENSITIZATION TO FLUORESCEINISOTHIOCYANATE", Fundamental and applied toxicology, 33(1), 1996, pp. 24-30

Abstract

What limited evidence there is indicates that the formulation in which a chemical allergen is encountered on the skin can have a marked impact upon the induction of cutaneous immune responses and the subsequent development of contact sensitization. The purpose of the present investigations was to examine further this phenomenon by analysis of the influence of dibutyl phthalate (DBP) on dermal sensitization to fluorescein isothiocyanate (FITC), a skin sensitizing fluorochrome. Additionof DBP augmented very substantially, in a dose-dependent fashion, theability of topically applied FITC to stimulate proliferative responses in mice by draining lymph node cells (LNC), a correlate of skin sensitizing potential. Under these conditions, exposure of mice to DBP alone failed to elicit significant LNC responses. The influence of DBP onthe accumulation of dendritic cells (DC) induced by FITC was examinedalso, Although 10% DBP had little effect on the numbers of DC found within draining nodes 18 hr following exposure of mice to FITC, the phthalate did result in a very substantial increase in the frequency of lymph node DC bearing detectable antigen (FITC+ DC). Furthermore, in the presence of DBP the median amount of FITC associated with antigen-bearing DC was higher. In vitro skin absorption studies indicated that DBP was associated with a small increase in percutaneous absorption of FITC, Collectively these data demonstrate that the vehicle formulationcan exert a marked influence on dermal sensitization and that one mechanism which may be relevant is the increased acquisition of antigen by DC, associated possibly with altered penetration of the allergen into or through the skin. (C) 1996 Society of Toxicology

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 03:46:43