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Titolo:
NA CONCENTRATION OF CSF AND CARDIOVASCULAR ADJUSTMENT IN THERMALLY DEHYDRATED RATS
Autore:
CHEN M;
Indirizzi:
KYOTO PREFECTURAL UNIV MED,DEPT PHYSIOL,KAMIGYO KU KYOTO 602 JAPAN
Titolo Testata:
Japanese Journal of Physiology
fascicolo: 1, volume: 46, anno: 1996,
pagine: 75 - 81
SICI:
0021-521X(1996)46:1<75:NCOCAC>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
HYPERTONIC NACL; BLOOD-PRESSURE; VASOPRESSIN; DOGS; SODIUM;
Keywords:
HYPEROSMOLALITY; CEREBROSPINAL FLUID; ARTERIAL PRESSURE; CARDIAC OUTPUT; HYPOVOLEMIA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
20
Recensione:
Indirizzi per estratti:
Citazione:
M. Chen, "NA CONCENTRATION OF CSF AND CARDIOVASCULAR ADJUSTMENT IN THERMALLY DEHYDRATED RATS", Japanese Journal of Physiology, 46(1), 1996, pp. 75-81

Abstract

To assess the effect of the Na concentration of cerebrospinal fluid (CSF) on arterial pressure regulation under dehydration, the Na concentration in CSF ([Na]csf) was measured continuously with an Na-sensitiveelectrode in the lateral ventricle (LV) together with mean arterial pressure (MAP), central venous pressure (CVP) and cardiac output (GO) during and after hypotonic infusion (INF, similar to 200 mOsm/kg H2O, 5mu l/min for 10 min) into the LV of dehydrated and pentobarbital anesthetized rats. Total vascular conductance (TVC) was calculated from CO/(MAP-CVP). Sine-aortic denervation was performed to eliminate any influence of arterial baroreflexes on MAP changed by [Na]csf. After dehydration, MAP increased by 20 mmHg (p<0.001) despite a 9% decrease in blood volume (p<0.001) while [Na]csf increased by 13 mEq/kg H2O (p<0.001). This increase in MAP was attributed to the decrease in TVC. After hypotonic INF began, MAP and [Na]csf decreased and the maximal decreases of -13 mmHg (p<0.001) and -28 mEq/kg H2O (p<0.001) were found at theend of INF, respectively. The changes in MAP (r=0.97, p<0.001), CO (r=0.97, p<0.001), and TVC (r=-0.90, p<0.001) were highly correlated with the change in [Na]csf during INF and the following 10-min recovery. These results suggest that the increase in [Na]csf is involved in the maintenance of arterial pressure by decreasing TVC and by attenuating the decrease in CO caused by dehydration-induced hypovolemia.

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Documento generato il 23/11/20 alle ore 21:41:20