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Titolo:
DILTIAZEM INHIBITS NALOXONE-PRECIPITATED AND SPONTANEOUS MORPHINE-WITHDRAWAL IN RATS
Autore:
KISHIOKA S; INOUE N; NISHIDA S; FUKUNAGA Y; YAMAMOTO H;
Indirizzi:
WAKAYAMA MED COLL,DEPT PHARMACOL,9 BANCHO 27 WAKAYAMA 640 JAPAN
Titolo Testata:
European journal of pharmacology
fascicolo: 1, volume: 316, anno: 1996,
pagine: 7 - 14
SICI:
0014-2999(1996)316:1<7:DINASM>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
DIHYDROPYRIDINE BINDING-SITES; CALCIUM-CHANNEL BLOCKERS; DEPENDENT RATS; ABSTINENCE; CLONIDINE; BRAIN;
Keywords:
DILTIAZEM; NALOXONE-PRECIPITATED WITHDRAWAL; MORPHINE WITHDRAWAL, SPONTANEOUS; CORTICOSTERONE, PLASMA; BODY WEIGHT LOSS; DIARRHEA; (RAT);
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
27
Recensione:
Indirizzi per estratti:
Citazione:
S. Kishioka et al., "DILTIAZEM INHIBITS NALOXONE-PRECIPITATED AND SPONTANEOUS MORPHINE-WITHDRAWAL IN RATS", European journal of pharmacology, 316(1), 1996, pp. 7-14

Abstract

The effects of diltiazem, a Ca2+ channel blocker, on naloxone-precipitated and spontaneous morphine withdrawal were studied in male Sprague-Dawley rats. In naloxone-precipitated withdrawal, body weight loss and plasma corticosterone elevation were dose dependently inhibited by diltiazem injected 4 or 2 and 4 h before naloxone, respectively. Three administrations of diltiazem (17, 11 and 5 h before naloxone) did not reduce the above withdrawal signs. Diarrhea was dose dependently inhibited by all schedule of diltiazem treatments. In spontaneous withdrawal, body weight loss and plasma corticosterone elevation were dose dependently inhibited by two (6 and 12 h) or three (6, 12 and 18 h after the last morphine) treatments with diltiazem at 6-h intervals after thelast morphine, but not by a single diltiazem injected 18 h after the last morphine.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 18:14:04