Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
BREAKPOINT DIVERSITY ILLUSTRATES DISTINCT MECHANISMS FOR ROBERTSONIANTRANSLOCATION FORMATION
Autore:
PAGE SL; SHIN JC; HAN JY; CHOO KHA; SHAFFER LG;
Indirizzi:
BAYLOR COLL MED,DEPT MOL & HUMAN GENET HOUSTON TX 77030 BAYLOR COLL MED,DEPT MOL & HUMAN GENET HOUSTON TX 77030 CATHOLIC UNIV,COLL MED,DEPT OBSTET & GYNECOL SEOUL SOUTH KOREA DONG A UNIV,COLL MED,DEPT CLIN PATHOL PUSAN SOUTH KOREA ROYAL CHILDRENS HOSP,MURDOCH INST RES BIRTH DEFECTS PARKVILLE VIC 3052 AUSTRALIA
Titolo Testata:
Human molecular genetics
fascicolo: 9, volume: 5, anno: 1996,
pagine: 1279 - 1288
SICI:
0964-6906(1996)5:9<1279:BDIDMF>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN ACROCENTRIC CHROMOSOMES; FLUORESCENCE INSITU HYBRIDIZATION; ALPHA-SATELLITE DNA; X-AUTOSOME TRANSLOCATION; MOLECULAR ANALYSIS; RIBOSOMAL DNA; III DNA; HOMOLOGOUS SEQUENCES; MUSCULAR-DYSTROPHY; CYTOGENETIC SURVEY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
81
Recensione:
Indirizzi per estratti:
Citazione:
S.L. Page et al., "BREAKPOINT DIVERSITY ILLUSTRATES DISTINCT MECHANISMS FOR ROBERTSONIANTRANSLOCATION FORMATION", Human molecular genetics, 5(9), 1996, pp. 1279-1288

Abstract

Robertsonian translocations are the most common chromosomal rearrangements in humans. The vast majority of the ten possible nonhomologous types of Robertsonian translocations ascertained are rob(13q14q) and rob(14q21q). Recombination between homologous sequences on nonhomologouschromosomes has been proposed as a mechanism leading to the preferential formation of rob(13q14q) and rob(14q21q). However, little evidenceexists to indicate whether the remaining less common Robertsonian translocations form through a similar mechanism. To better elucidate the mechanisms involved in Robertsonian translocation formation, we have used fluorescence in situ hybridization to localize the breakpoints in 56 nonhomologous Robertsonian translocations. This study revealed highly variable locations of breakpoints in seven types of the less commonRobertsonians, while nearly all rob(13q14q) and rob(14q21q) analyzed displayed breakpoints in the same locations, Therefore, this study provides direct evidence that rob(13q14q) and rob(14q21q) form through a specific mechanism, possibly involving homologous recombination, whichis distinct from the mechanism(s) that contributes to the formation of the remaining types of Robertsonian translocations.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/09/20 alle ore 10:59:45