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Titolo:
INTERFERON-ALPHA FOR THE TREATMENT OF CHRONIC HEPATITIS-C IN PATIENTSINFECTED WITH HUMAN-IMMUNODEFICIENCY-VIRUS
Autore:
SORIANO V; GARCIASAMANIEGO J; BRAVO R; GONZALEZ J; CASTRO A; CASTILLA J; MARTINEZODRIOZOLA P; COLMENERO M; CARBALLO E; SUAREZ D; RODRIGUEZPINERO FJ; MORENO A; DELROMERO J; PEDREIRA J; GONZALEZLAHOZ J; LOPEZCALVO S; LLIBRE JM; SANTAMARIA JM; GONZALEZANGLADA I; MARTINEZZAPICO R; VAZQUEZ JJ; MARTINEZVAZQUEZ JM; RODRIGUEZ C; GARCIA S; MARTIN R; BRU F; VICARIO JL; ARROYO E; COSIN J; ZABAY JM; MAS A; MUNOZ F;
Indirizzi:
CALLE RAFAEL CALVO 7,2 A MADRID 28010 SPAIN HOSP RAMON Y CAJAL,HOSP LA PAZ,INST SALUD CARLOS III,CTR NACL EPIDEMIOL E-28034 MADRID SPAIN HOSP RAMON Y CAJAL,HOSP LA PAZ,INST SALUD CARLOS III,CTR INVEST CLIN E-28034 MADRID SPAIN CTR SANDOVAL,COMUNIDAD MADRID MADRID SPAIN HOSP JUAN CANALEJO LA CORUNA SPAIN HOSP BASURTO BILBAO SPAIN HOSP VIRGEN MACARENA SEVILLE SPAIN HOSP XERAL GALICIA SANTIAGO COMPOSTE SPAIN HOSP ARQUITECTO MARCIDE EL FERROL SPAIN HOSP CALELLA BARCELONA SPAIN CPS,AYUNTAMIENTO MADRID MADRID SPAIN REG TRANSFUS CTR,COMUNIDAD MADRID MADRID SPAIN HOSP GEN GREGORIO MARANON MADRID SPAIN
Titolo Testata:
Clinical infectious diseases
fascicolo: 3, volume: 23, anno: 1996,
pagine: 585 - 591
SICI:
1058-4838(1996)23:3<585:IFTTOC>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
NON-B HEPATITIS; PLACEBO-CONTROLLED TRIAL; CHRONIC NON-A; LIVER-DISEASE; OPPORTUNISTIC INFECTIONS; HIV-INFECTION; SYNDROME AIDS; ALFA THERAPY; RNA LEVELS; HEMOPHILIACS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
40
Recensione:
Indirizzi per estratti:
Citazione:
V. Soriano et al., "INTERFERON-ALPHA FOR THE TREATMENT OF CHRONIC HEPATITIS-C IN PATIENTSINFECTED WITH HUMAN-IMMUNODEFICIENCY-VIRUS", Clinical infectious diseases, 23(3), 1996, pp. 585-591

Abstract

Liver disease secondary to hepatitis C virus (HCV) infection is a rising cause of morbidity and mortality among individuals who have been infected parenterally with human immunodeficiency virus (HIV) such as injection drug users, hemophiliacs, and transfused patients. We analyzed both the efficacy of interferon (IFN) cu therapy in these patients and the predictors of response to this agent. A total of 119 patients with chronic hepatitis C (90 of whom were infected with HIV and 29 of whom were not) were included in a multicenter, prospective, open, nonrandomized observational study. IFN-alpha was given subcutaneously in a dosage of 5 million units three times a week during a 3-month period; those patients who responded received a dose of 3 million units given subcutaneously three times a week for an additional 9 months. One hundred seven patients completed the study; the level of aminotransferasesreturned to normal and sera became negative (complete response) for HCV RNA in 26 (32.5%) of 80 HIV-infected patients and 10 (37.0%) of 27 non-HIV-infected patients (P = .666) after completion of the treatment. Two variables were independently associated with a response in HIV-infected patients: a CD4(+) T lymphocyte count of > 500 x 10(6)/L and abaseline HCV viremia level of < 10(7) copies/mL. In the 12 months following treatment, relapses occurred in 30.8% of the HIV-infected patients and 12.5% of non-HIV-infected patients (P = .403).

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/07/20 alle ore 00:48:26