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Titolo:
RANDOMIZED COMPARISON OF AMPHOTERICIN-B DEOXYCHOLATE DISSOLVED IN DEXTROSE OR INTRALIPID FOR THE TREATMENT OF AIDS-ASSOCIATED CRYPTOCOCCAL MENINGITIS
Autore:
JOLY V; AUBRY P; NDAYIRAGIDE A; CARRIERE I; KAWA E; MLIKACABANNE N; ABOULKER JP; COULAUD JP; LAROUZE B; YENI P;
Indirizzi:
HOP BICHAT CLAUDE BERNARD,46 RUE HENRI HUCHARD F-75877 PARIS 18 FRANCE HOP BICHAT CLAUDE BERNARD F-75877 PARIS 18 FRANCE INSERM U13 PARIS FRANCE HOP ROBERT PICQUE BORDEAUX FRANCE INSERM,COMMUN 10 VILLEJUIF FRANCE CHU KAMENGE BUJAMBURA BURUNDI
Titolo Testata:
Clinical infectious diseases
fascicolo: 3, volume: 23, anno: 1996,
pagine: 556 - 562
SICI:
1058-4838(1996)23:3<556:RCOADD>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACQUIRED-IMMUNODEFICIENCY-SYNDROME; NEUTROPENIC PATIENTS; FUNGAL-INFECTIONS; RENAL TOXICITY; FLUCONAZOLE; AMBISOME; TRIAL; TOLERANCE; EFFICACY; EMULSION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
24
Recensione:
Indirizzi per estratti:
Citazione:
V. Joly et al., "RANDOMIZED COMPARISON OF AMPHOTERICIN-B DEOXYCHOLATE DISSOLVED IN DEXTROSE OR INTRALIPID FOR THE TREATMENT OF AIDS-ASSOCIATED CRYPTOCOCCAL MENINGITIS", Clinical infectious diseases, 23(3), 1996, pp. 556-562

Abstract

We conducted a randomized, open-labeled clinical trial to compare thetolerability and efficacy of amphotericin B deoxycholate, prepared in5% dextrose or Intralipid (Kabi Pharmacia, Saint-Quentin-en-Yvelines,France), in the treatment of AIDS-associated cryptococcal meningitis in Burundi. Forty-four patients were assigned to receive amphotericin B/dextrose (0.7 mg/[kg . d]) for 14 days; the dose was then reduced to1 mg/kg every other day for 28 days (infused over 6 hours). Forty-sixpatients were assigned to receive Intralipid/amphotericin B at a 50% higher dosage (1 mg/[kg . d]) for 14 days; the dose was then reduced to 1.5 mg/kg every other day for 28 days (infused over 2 hours). Intralipid significantly decreased the incidence of fever (P = .02) and chills (P = .0001) related to the infusion of amphotericin B deoxycholate. Analysis of the time to the onset of increased levels of serum creatinine (creatinine level, > 150 mu mol/L) showed that Intralipid/amphotericin B was more nephrotoxic (P = .03). The percentage of patients whowere clinically cured or had improvement in their conditions and successful mycological outcome was similar in both therapeutic groups, butanalysis of the time to the first negative cerebrospinal fluid culture showed a nearly significant difference that favored Intralipid/amphotericin B (P = .07). Intralipid reduced the infusion-related toxicity of amphotericin B deoxycholate without altering its antifungal efficacy but did not confer substantial benefit against renal toxicity that would allow the unitary dosage of amphotericin B deoxycholate to be increased safely.

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Documento generato il 21/09/20 alle ore 09:46:16