Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
RANDOMIZED CONTROLLED TRIAL OF THE EFFECT OF MANNITOL ON RENAL REPERFUSION INJURY DURING AORTIC-ANEURYSM SURGERY
Autore:
NICHOLSON ML; BAKER DM; HOPKINSON BR; WENHAM PW;
Indirizzi:
LEICESTER GEN HOSP,DEPT SURG,GWENDOLEN RD LEICESTER LE5 4PW LEICS ENGLAND UNIV NOTTINGHAM HOSP NOTTINGHAM NG7 2UH ENGLAND
Titolo Testata:
British Journal of Surgery
fascicolo: 9, volume: 83, anno: 1996,
pagine: 1230 - 1233
SICI:
0007-1323(1996)83:9<1230:RCTOTE>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
OXYGEN FREE-RADICALS; PULMONARY-EDEMA; FAILURE; PREVENTION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
22
Recensione:
Indirizzi per estratti:
Citazione:
M.L. Nicholson et al., "RANDOMIZED CONTROLLED TRIAL OF THE EFFECT OF MANNITOL ON RENAL REPERFUSION INJURY DURING AORTIC-ANEURYSM SURGERY", British Journal of Surgery, 83(9), 1996, pp. 1230-1233

Abstract

The effects of mannitol on renal impairment following infrarenal aortic aneurysm repair were studied. Patients received either mannitol 0.3g/kg (n = 15) or saline (n = 13) as a rapid intravenous infusion before aortic cross-clamping. One patient in the control group developed fatal postoperative renal failure but there was no renal failure in themannitol group. Two patients treated with mannitol died from perioperative myocardial infarction. There were no significant differences in postoperative blood urea level, serum creatinine concentration or creatinine clearance between mannitol and control groups. In patients who had mannitol there was a significant diuresis on the first day after operation (mean urine output 2250 ml) compared with before operation (1557 ml) (P = 0.007). Compared with controls, patients treated with mannitol had lower mean (s.e.m.) postoperative levels of urinary albumin (160(32) versus 500(140) mg per mmol creatinine; P = 0.036) and N-acetyl glucosaminidase (143(34) versus 271(70) mu mol per mmol creatinine;P = 0.04) indicating a reduced level of subclinical glomerular and renal tubular damage. These data demonstrate that mannitol reduces subclinical renal injury following infrarenal aortic aneurysm repair.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/11/20 alle ore 09:00:17