Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
QUANTITATIVE IMAGING OF I-124 WITH PET
Autore:
PENTLOW KS; GRAHAM MC; LAMBRECHT RM; DAGHIGHIAN F; BACHARACH SL; BENDRIEM B; FINN RD; JORDAN K; KALAIGIAN H; KARP JS; ROBESON WR; LARSON SM;
Indirizzi:
MEM SLOAN KETTERING CANC CTR,DEPT MED PHYS,1275 YORK AVE NEW YORK NY 10021 MEM SLOAN KETTERING CANC CTR,DEPT RADIOL NEW YORK NY 10021 N SHORE UNIV HOSP MANHASSET NY 00000 NIH BETHESDA MD 20892 BROOKHAVEN NATL LAB UPTON NY 11973 HANNOVER MED SCH HANNOVER GERMANY HOSP UNIV PENN PHILADELPHIA PA 19104 KING FAISAL SPECIALIST HOSP & RES CTR RIYADH 11211 SAUDI ARABIA
Titolo Testata:
The Journal of nuclear medicine
fascicolo: 9, volume: 37, anno: 1996,
pagine: 1557 - 1562
SICI:
0161-5505(1996)37:9<1557:QIOIWP>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON EMISSION TOMOGRAPHY; MONOCLONAL-ANTIBODIES; COMPUTED-TOMOGRAPHY; PERFORMANCE-CHARACTERISTICS; NEURO-BLASTOMA; BREAST-CANCER; HUMAN TUMOR; I-124; RADIOIMMUNOTHERAPY; DOSIMETRY;
Keywords:
PET; I-124; QUANTITATIVE IMAGING;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
34
Recensione:
Indirizzi per estratti:
Citazione:
K.S. Pentlow et al., "QUANTITATIVE IMAGING OF I-124 WITH PET", The Journal of nuclear medicine, 37(9), 1996, pp. 1557-1562

Abstract

PET is potentially very useful for the accurate in vivo quantitation of time-varying biological distributions of radiolabeled antibodies over several days. The short half-lives of most commonly used positron-emitting nuclides make them unsuitable for this purpose. Iodine-124 is a positron emitter with a half-life of 4.2 days and appropriate chemical properties. It has not been widely used because of a complex decay scheme including several high energy gamma rays. However, measurementsmade under realistic conditions on several different PET scanners have shown that satisfactory imaging and quantitation can be achieved. Methods: Whole-body and head-optimized scanners with different detectors(discrete BGO, block BGO and BaF2 time-of-flight), different septa and different correction schemes were used. Measurements of resolution, quantitative linearity and the ability to quantitatively image spheresof different sizes and activities in different background activities were made using phantoms. Results: Compared with conventional PET nuclides, resolution and quantitation were only slightly degraded. Sphere detectability was also only slightly worse if imaging time was increased to compensate for the lower positron abundance. Conclusion: Quantitative imaging with I-124 appears to be possible under realistic conditions with various PET scanners.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 13/07/20 alle ore 16:47:51