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Titolo:
IMMUNE-RESPONSE TO POLYVALENT MELANOMA CELL VACCINE IN AJCC STAGE-IIIMELANOMA - AN IMMUNOLOGICAL SURVIVAL MODEL
Autore:
JONES RC; KELLEY M; GUPTA RK; NIZZE JA; YEE R; LEOPOLDO Z; QI K; STERN S; MORTON DL;
Indirizzi:
JOHN WAYNE CANC INST,2200 SANTA MONICA BLVD SANTA MONICA CA 90404 ST JOHNS HOSP,JOHN WAYNE CANC INST,ROY E COATS RES LABS SANTA MONICA CA 00000
Titolo Testata:
Annals of surgical oncology
fascicolo: 5, volume: 3, anno: 1996,
pagine: 437 - 445
SICI:
1068-9265(1996)3:5<437:ITPMCV>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-ASSOCIATED ANTIGEN; ACTIVE SPECIFIC IMMUNOTHERAPY; CD4+ T-CELLS; METASTATIC MELANOMA; MALIGNANT-MELANOMA; MONOCLONAL-ANTIBODY; PROGNOSTIC FACTORS; IGM ANTIBODY; CANCER; GROWTH;
Keywords:
MELANOMA; VACCINE; SURVIVAL; ADJUVANT IMMUNOTHERAPY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
38
Recensione:
Indirizzi per estratti:
Citazione:
R.C. Jones et al., "IMMUNE-RESPONSE TO POLYVALENT MELANOMA CELL VACCINE IN AJCC STAGE-IIIMELANOMA - AN IMMUNOLOGICAL SURVIVAL MODEL", Annals of surgical oncology, 3(5), 1996, pp. 437-445

Abstract

Background: Our polyvalent, allogeneic melanoma cell vaccine (MCV) induces immunoglobulin M (IgM) and immunoglobulin G (IgG) class antibodies to a 90-kDa glycoprotein melanoma-associated antigen (MAA). Additionally, MCV induces delayed-type hypersensitivity (DTH) responses that we previously correlated with survival. We hypothesized that early DTHresponses to MCV and early humoral responses to the 90-kDa MAA expressed on MCV cells may be predictive of overall survival. We tested thishypothesis by monitoring immunologic profiles in 59 patients with melanoma who were receiving MCV after surgical resection of regional lymph node or soft-tissue metastases. Methods: Blood was drawn before vaccine administration, biweekly for 6 weeks, and then monthly. DTH to MCVwas recorded at 0, 2, 4, and 8 weeks of MCV therapy. Mean antibody titers during the first 6-week interval were calculated. Changes in DTH were calculated as the difference between peak and prevaccine values (Delta DTH). Results: At a median follow-up of 75.6 months (range 5-138), univariate analysis assigned prognostic significance to gender (p =0.046), lymph node involvement (p = 0.024), Delta DTH (p = 0.044), mean anti-90-kDa MAA IgG (p = 0.0009), and mean anti-90-kDa MAA IgM (p =0.0014). In multifactorial analysis, only the three immunologic variables significantly impacted survival (p = 0.046, 0.0005, and 0.0053, respectively). A mathematical model based on Delta DTH and mean anti-90-kDa MAA IgG and IgM titers closely approximated the observed individual and overall survival rates. Conclusions: The correlation between overall survival and initial humoral/cellular immune responses to MCV immunotherapy may be useful in selecting patients most likely to benefitfrom prolonged adjuvant immunotherapy.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 13:59:17