Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
ANALYSIS OF PROLIFERATION MARKERS AND P53 EXPRESSION IN GLIOMAS OF ASTROCYTIC ORIGIN - RELATIONSHIPS AND PROGNOSTIC VALUE
Autore:
CUNNINGHAM JM; KIMMEL DW; SCHEITHAUER BW; OFALLON JR; NOVOTNY PJ; JENKINS RB;
Indirizzi:
MAYO CLIN & MAYO FDN,LAB GENET HI970,DEPT LAB MED,200 1ST ST SW ROCHESTER MN 55905 MAYO CLIN & MAYO FDN,LAB GENET HI970,DEPT LAB MED ROCHESTER MN 55905 MAYO CLIN & MAYO FDN,LAB GENET HI970,DEPT PATHOL ROCHESTER MN 55905 MAYO CLIN & MAYO FDN,DEPT NEUROL ROCHESTER MN 55905 MAYO CLIN & MAYO FDN,CANC CTR STAT ROCHESTER MN 55905
Titolo Testata:
Journal of neurosurgery
fascicolo: 1, volume: 86, anno: 1997,
pagine: 121 - 130
SICI:
0022-3085(1997)86:1<121:AOPMAP>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
CELL NUCLEAR ANTIGEN; BROMODEOXYURIDINE LABELING INDEX; NERVOUS-SYSTEM NEOPLASMS; CYCLIN-DEPENDENT KINASES; LOW-GRADE ASTROCYTOMAS; BRAIN-TUMOR SPECIMENS; GLIOBLASTOMA-MULTIFORME; MONOCLONAL-ANTIBODIES; FLOW-CYTOMETRY; TP53 GENE;
Keywords:
GLIOMA; P53; PROLIFERATING CELL NUCLEAR ANTIGEN; MIB-1;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
72
Recensione:
Indirizzi per estratti:
Citazione:
J.M. Cunningham et al., "ANALYSIS OF PROLIFERATION MARKERS AND P53 EXPRESSION IN GLIOMAS OF ASTROCYTIC ORIGIN - RELATIONSHIPS AND PROGNOSTIC VALUE", Journal of neurosurgery, 86(1), 1997, pp. 121-130

Abstract

Consecutive paraffin sections of 105 astrocytomas and 15 oligoastrocytomas were examined for expression of p53, MIB-1 (Ki-67), and proliferating cell nuclear antigen (PCNA). The tumors had been examined previously for genetic abnormalities and by flow cytometry. Regardless of the tumor's stage and grade and the patient's age and gender, p53 expression was found in 40% of tumors. Although p53 expression was associated with a loss on chromosome 17p and was more frequent in aneuploid tumors, it had no association with survival time. The MIB-1 and PCNA labeling indices increased with increasing tumor grade but showed no association with other clinicopathological parameters. In individual tumors, there was poor concordance between any of the variables (MIB-1, PCNA, and p53). Results for p53 and MIB-1 were similar for both astrocytomas and oligoastrocytomas. The MIB-1 and PCNA values appeared to have prognostic utility in univariate analysis but not after adjusting for patient age and tumor grade. The poor concordance between MIB-1 and PCNA in individual tumors indicates that any one means of assessing proliferative potential in gliomas may not be reliable.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 15:24:03