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Titolo:
MEDULLOBLASTOMA - IS THE 5-YEAR SURVIVAL RATE IMPROVING - A REVIEW OF80 CASES FROM A SINGLE INSTITUTION
Autore:
DAVID KM; CASEY ATH; HAYWARD RD; HARKNESS WFJ; PHIPPS K; WADE AM;
Indirizzi:
GREAT ORMOND ST HOSP CHILDREN NHS TRUST,DEPT NEUROSURG,GREAT ORMOND ST LONDON WC1N 3JH ENGLAND GREAT ORMOND ST HOSP CHILDREN NHS TRUST,DEPT NEUROSURG LONDON WC1N 3JH ENGLAND INST CHILD HLTH,DEPT EPIDEMIOL & BIOSTAT LONDON ENGLAND
Titolo Testata:
Journal of neurosurgery
fascicolo: 1, volume: 86, anno: 1997,
pagine: 13 - 21
SICI:
0022-3085(1997)86:1<13:M-IT5S>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
PRIMITIVE NEUROECTODERMAL TUMORS; POSTERIOR-FOSSA SURGERY; CHILDHOOD MEDULLOBLASTOMA; ADJUVANT CHEMOTHERAPY; RADIATION-THERAPY; PROGNOSTIC FACTORS; CEREBELLAR MUTISM; BRAIN-TUMORS; CHILDREN; VINCRISTINE;
Keywords:
MEDULLOBLASTOMA; SURVIVAL RATE; SPINAL INVESTIGATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
58
Recensione:
Indirizzi per estratti:
Citazione:
K.M. David et al., "MEDULLOBLASTOMA - IS THE 5-YEAR SURVIVAL RATE IMPROVING - A REVIEW OF80 CASES FROM A SINGLE INSTITUTION", Journal of neurosurgery, 86(1), 1997, pp. 13-21

Abstract

A series of 80 cases of medulloblastomas in children undergoing operation and postoperatively followed between 1980 and 1990 at Great Ormond Street Hospital for Children (GOSH) has been reviewed and compared to an earlier series reported from the same institution by McIntosh. The overall 5-year survival rate for the present series was 50%, although three patients died after surviving 5 years. The operative mortalityrate was 5%. Survival analysis revealed that the presence or absence of spinal metastases and the necessity for some form of cerebrospinal fluid diversion within 30 days of the operation independently significantly affected survival in this series. Those patients with no spinal metastasis and total tumor removal had a 5-year survival rate of 73%, making this the most favorable subgroup in the series. Patient age andgender, duration of symptoms, Chang T stages, tumor volume, extent ofresection, and postoperative chemotherapy were not significant variables. Although these results are better than those reported in the earlier GOSH series, they are not significantly different from the resultsof the second 5-year cohort of patients described in that article. Radiotherapy remains the greatest advance in treatment, although it is hoped that further improvement will result from the various chemotherapy protocols now being studied and from increasing knowledge of the biological behavior of these tumors.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 07:54:15