Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
MEANINGS OF C-ERBB AND INT-2 AMPLIFICATION IN SUPERFICIAL ESOPHAGEAL SQUAMOUS-CELL CARCINOMAS
Autore:
IKEDA Y; OZAWA S; ANDO N; KITAGAWA Y; UEDA M; KITAJIMA M;
Indirizzi:
KEIO UNIV,SCH MED,DEPT SURG,SHINJUKU KU,35 SHINANOMACHI TOKYO 160 JAPAN KEIO UNIV,SCH MED,DEPT SURG,SHINJUKU KU TOKYO 160 JAPAN
Titolo Testata:
The Annals of thoracic surgery
fascicolo: 3, volume: 62, anno: 1996,
pagine: 835 - 838
SICI:
0003-4975(1996)62:3<835:MOCAIA>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
CANCER; SEQUENCE; GENE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
12
Recensione:
Indirizzi per estratti:
Citazione:
Y. Ikeda et al., "MEANINGS OF C-ERBB AND INT-2 AMPLIFICATION IN SUPERFICIAL ESOPHAGEAL SQUAMOUS-CELL CARCINOMAS", The Annals of thoracic surgery, 62(3), 1996, pp. 835-838

Abstract

Background. Accumulation of genetic abnormalities is linked to the development and progression of cancer. We therefore analyzed the correlation between the clinical characteristics of superficial esophageal squamous cell carcinoma patients and oncogene amplifications. Methods. Between 1980 and 1991, there were 63 cases of superficial esophageal carcinoma (Tis and T1 cancer) at Keio University Hospital. The T1 cases were divided into two groups: Tla cases, in which the tumor had invaded the lamina propria, and T1b cases, in which the tumor had invaded the submucosa. DNA was isolated from paraffin-embedded blocks. Oncogene amplification was determined by slot-blot hybridization. Results. Amplification of int-2 and c-erbB was detected in 14 and 5, respectively, of the 54 cases. Three of 12 T1b patients with int-2 amplification died of distant organ metastasis. The survival rate for the group with int-2 amplification was significantly lower than that without int-2 amplification. All 4 T1b patients with c-erbB amplification had lymph nodemetastasis at operation. Conclusions. These findings mean that genetic abnormalities are a useful marker for treating patients with superficial esophageal squamous cell carcinomas.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/21 alle ore 00:26:32