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Titolo:
THE EFFECT OF SPECIFIC HORMONES ON FIBRINOLYSIS IN PREGNANCY
Autore:
HOULIHAN CM; KNUPPEL RA; VINTZILEOS AM; GUO JZ; HAHN DW;
Indirizzi:
132 WINDING WAY MORRISVILLE PA 19067 UNIV MED & DENT NEW JERSEY,ROBERT WOOD JOHNSON MED SCH,DIV MATERNAL FETAL MED NEW BRUNSWICK NJ 00000 ROBERT WOOD JOHNSON PHARMACEUT RES INST RARITAN NJ 00000
Titolo Testata:
American journal of obstetrics and gynecology
fascicolo: 1, volume: 175, anno: 1996,
pagine: 168 - 172
SICI:
0002-9378(1996)175:1<168:TEOSHO>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
PLASMINOGEN-ACTIVATOR INHIBITOR; ORAL-CONTRACEPTIVES; ENDOTHELIAL-CELLS; GROWTH-RETARDATION; DEXAMETHASONE; PREECLAMPSIA; COAGULATION; VARIABLES; DISEASE; TYPE-1;
Keywords:
TISSUE-TYPE PLASMINOGEN ACTIVATOR; PLASMINOGEN ACTIVATOR INHIBITOR-1; ENDOTHELIUM; PREGNANCY; ESTRADIOL-17-BETA; PROGESTERONE; PROLACTIN; HYDROCORTISONE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
26
Recensione:
Indirizzi per estratti:
Citazione:
C.M. Houlihan et al., "THE EFFECT OF SPECIFIC HORMONES ON FIBRINOLYSIS IN PREGNANCY", American journal of obstetrics and gynecology, 175(1), 1996, pp. 168-172

Abstract

OBJECTIVE: Plasminogen activator inhibitor-1, the major serum protease inhibitor of fibrinolysis, increases steadily during pregnancy. The study objective was to examine four hormones, namely, estradiol-17 beta, progesterone, prolactin, and hydrocortisone to determine their individual contributions in the production of tissue plasminogen activatorantigen, plasminogen activator inhibitor-1 antigen, and plasminogen activator inhibitor-1 activity. STUDY DESIGN: Human umbilical vein endothelial cells were grown with physiologic third-trimester concentrations of the above hormones, and fibrinolytic parameters were measured. RESULTS: Of the four hormones evaluated, only hydrocortisone significantly increased plasminogen activator inhibitor-1 antigen and activity at both concentrations tested (p < 0.001). Estradiol-17 beta significantly increased tissue plasminogen activator antigen and progesterone significantly decreased tissue plasminogen activator antigen, but neither affected the overall fibrinolytic balance. CONCLUSION: Hydrocortisone demonstrated antifibrinolytic properties at physiologic concentrations in pregnancy, suggesting that there may be a role for hydrocortisone in the prothrombotic tendency associated with pregnancy. The overallprocess of fibrinolysis was unaffected by estradiol-17 beta, progesterone, or prolactin.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 01:19:39