Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
STEREOSELECTIVE SYNTHESIS OF LEWIS-ASSOCIATED TRISACCHARIDES AS E-SELECTIN INHIBITORS
Autore:
IMAZAKI N; KOIKE H; MIYAUCHI H; HAYASHI M;
Indirizzi:
SUMITOMO PHARMACEUT CO LTD,RES CTR,KONOHANA,1-98 KASUGADENAKA 3 CHOMEOSAKA 554 JAPAN
Titolo Testata:
Bioorganic & medicinal chemistry letters
fascicolo: 17, volume: 6, anno: 1996,
pagine: 2043 - 2048
SICI:
0960-894X(1996)6:17<2043:SSOLTA>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
LIGAND; FUCOSE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
18
Recensione:
Indirizzi per estratti:
Citazione:
N. Imazaki et al., "STEREOSELECTIVE SYNTHESIS OF LEWIS-ASSOCIATED TRISACCHARIDES AS E-SELECTIN INHIBITORS", Bioorganic & medicinal chemistry letters, 6(17), 1996, pp. 2043-2048

Abstract

Three types of Lewis-associated trisaccharides [the Le(a) analogs, their epimers with respect to the fucose residue (the 1c-epi-Le(a) analogs), and the Le(X) analogs] were synthesized in a stereoselective manner. Not only the Le(a) analogs but also the 1c-epi-Le(a) analogs inhibited E-selectin-mediated neutrophil accumulation into pleural cavity in lipoteichoic acid-treated mice, with the trend being Le(a) > 1c-epi-Le(a) > Le(X). Copyright (C) 1996 Elsevier Science Ltd

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 12:41:53