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Titolo:
DIBENZOAZEPINE ANALOGS - THE ELECTROPHYSIOLOGICAL PROPERTIES OF JL3, A POTENTIAL ATYPICAL ANTIDEPRESSANT
Autore:
LIEGEOIS JF; SCUVEEMOREAU J; GIESBERS I; DAMAS J; BRUHWYLER J; GECZY J; DELARGE J; DRESSE A;
Indirizzi:
UNIV LIEGE,LAB MED CHEM & PHYSIOL,RUA FUSCH 3 B-4000 LIEGE BELGIUM UNIV LIEGE,MED CHEM LAB B-4000 LIEGE BELGIUM UNIV LIEGE,PHYSIOL LAB B-4000 LIEGE BELGIUM UNIV LIEGE,PHARMACOL LAB B-4000 LIEGE BELGIUM THERABEL RES BRUSSELS BELGIUM
Titolo Testata:
European journal of pharmacology
fascicolo: 1, volume: 310, anno: 1996,
pagine: 9 - 12
SICI:
0014-2999(1996)310:1<9:DA-TEP>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
SPONTANEOUS FIRING RATE; DORSAL RAPHE; NEURONS; DERIVATIVES; CLOZAPINE; DRUGS;
Keywords:
JL3 LPIPERAZIN-1-YL)PYRIDO[4,3-B][1,4]BENZOTHIAZEPINE); ANTIDEPRESSANT; DORSAL RAPHE; LOCUS CERULEUS; A10 DOPAMINE NEURON; ELECTROPHYSIOLOGY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
15
Recensione:
Indirizzi per estratti:
Citazione:
J.F. Liegeois et al., "DIBENZOAZEPINE ANALOGS - THE ELECTROPHYSIOLOGICAL PROPERTIES OF JL3, A POTENTIAL ATYPICAL ANTIDEPRESSANT", European journal of pharmacology, 310(1), 1996, pp. 9-12

Abstract

JL3, lpiperazin-1-yl)pyrido[4,3-b][1,4]benzothiazepine, has potent antidepressant-like activity in Porsolt's test in mice. Therefore, its influence on the electrical activity of central monoaminergic neurons was investigated in rats anaesthetized with chloral hydrate. JL3 induced a marked decrease of the firing rate of dorsal raphe serotonergic neurons (ID50 = 3.87 +/- 0.57 mg kg(-1)) and of locus coeruleus noradrenergic neurons (ID50 = 2.63 +/- 0.35 mg kg(-1)). The drug did not modify the electrical activity of A10 dopaminergic neurons. JL3 does not block amine uptake but it has affinity for 5-HT1A and 5-HT2 receptors. It is speculated that serotonergic mechanisms could play a role in the electrophysiological effects of JL3.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/07/20 alle ore 08:05:39