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Titolo:
INCREASED LEVELS OF INTERLEUKIN-6 (IL-6) IN SERUM AND SPONTANEOUS IN-VITRO PRODUCTION OF IL-6 BY LYMPH-NODE MONONUCLEAR-CELLS OF PATIENTS WITH ANGIOIMMUNOBLASTIC LYMPHADENOPATHY WITH DYSPROTEINEMIA (AILD), ANDCLINICAL EFFECTIVENESS OF CYCLOSPORINE-A
Autore:
YAMAMURA M; HONDA M; YAMADA Y; ITOYAMA T; SOHDA H; YUBASHI T; MOMITA S; KAMIHIRA S; OHMOTO Y; TOMONAGA M;
Indirizzi:
NAGASAKI UNIV,SCH MED,DEPT HEMATOL,INST ATOM DIS,1-12-4 SAKAMOTO NAGASAKI 852 JAPAN NAGASAKI UNIV HOSP,DEPT LAB MED NAGASAKI JAPAN OHTSUKA PHARMACEUT INC,CELLULAR TECHNOL INST TOKUSHIMA JAPAN
Titolo Testata:
Leukemia
fascicolo: 9, volume: 10, anno: 1996,
pagine: 1504 - 1508
SICI:
0887-6924(1996)10:9<1504:ILOI(I>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACUTE-PHASE RESPONSE; ANGIOIMMUNOBLASTIC LYMPHADENOPATHY; CASTLEMANS DISEASE; HODGKINS-DISEASE; POEMS SYNDROME; DIFFERENTIATION; PROTEIN; EXPRESSION; CORRELATE; DIAGNOSIS;
Keywords:
ANGIOIMMUNOBLASTIC LYMPHADENOPATHY WITH DYSPROTEINEMIA (AILD); IMMUNOSUPPRESSIVE THERAPY; CYCLOSPORINE A(CSA); INTERLEUKIN-6 (IL-6); CYTOKINES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
34
Recensione:
Indirizzi per estratti:
Citazione:
M. Yamamura et al., "INCREASED LEVELS OF INTERLEUKIN-6 (IL-6) IN SERUM AND SPONTANEOUS IN-VITRO PRODUCTION OF IL-6 BY LYMPH-NODE MONONUCLEAR-CELLS OF PATIENTS WITH ANGIOIMMUNOBLASTIC LYMPHADENOPATHY WITH DYSPROTEINEMIA (AILD), ANDCLINICAL EFFECTIVENESS OF CYCLOSPORINE-A", Leukemia, 10(9), 1996, pp. 1504-1508

Abstract

Serum levels of cytokines and in vitro cytokine production by lymph node mononuclear cells (LNMC) were studied in four patients with angio-immunoblastic lymphadenopathy with dysproteinemia (AILD) or AILD-type T cell lymphoma. An increased level of serum interleukin-6 (IL-6) was detected on initial diagnosis in both of two patients examined. Spontaneous production of IL-6 by LNMC was detected in all four patients studied. Immunosuppressive therapy with cyclosporin A (CsA) was attemptedin a 68-year-old man, who was refractory to intensive combination chemotherapy. The increased level of IL-6 in this patient decreased to normal within 3 weeks of CsA administration and the patient became symptom-free. One and a half months later, the IL-6 level gradually increased along with clinical exacerbation. We also measured serum levels of IL-1 alpha, IL-2, IL-4, IFN-alpha, gamma and TNF-alpha in parallel with IL-6, but these factors were only sporadically detected. IL-6 production by LNMC was stimulated by IL-2 but inhibited by CsA. These observations suggest that IL-6 is one of the important cytokines to be involved in the pathophysiology of AILD and CsA is a useful reagent for relieving symptoms.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 10:17:47