Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
TESTOSTERONE-INDUCED INCREASE OF INSULIN-LIKE GROWTH-FACTOR-I LEVELS DEPENDS UPON NORMAL LEVELS OF GROWTH-HORMONE
Autore:
SAGGESE G; CESARETTI G; FRANCHI G; STARTARI L;
Indirizzi:
UNIV PISA,DEPT PEDIAT,ENDOCRINE UNIT,VIA ROME 67 I-56125 PISA ITALY
Titolo Testata:
European journal of endocrinology
fascicolo: 2, volume: 135, anno: 1996,
pagine: 211 - 215
SICI:
0804-4643(1996)135:2<211:TIOIGL>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
SOMATOMEDIN-C CONCENTRATIONS; PRECOCIOUS PUBERTY; IGF-I; CHILDREN; SECRETION; ADOLESCENCE; DEFICIENCY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
33
Recensione:
Indirizzi per estratti:
Citazione:
G. Saggese et al., "TESTOSTERONE-INDUCED INCREASE OF INSULIN-LIKE GROWTH-FACTOR-I LEVELS DEPENDS UPON NORMAL LEVELS OF GROWTH-HORMONE", European journal of endocrinology, 135(2), 1996, pp. 211-215

Abstract

Pubertal development is associated with a rise in plasma insulin-likegrowth factor I(IGF-I) levels that is related both to the increase insex steroids and/or to the sex steroid-induced augmentation in endogenous growth hormone (GH) secretion. In order to investigate the relationship between IGF-I, GH and testosterone, we examined 12 male subjects with various clinical conditions (classical GH deficiency (CGHD, N =5), non-classical GH deficiency (NCGHD, N = 7), short idiopathic stature (N = 6), nutritional obesity (N = 8), GH-treated CGHD (N = 4), GH-treated NCGHD (N = 5) and normal stature (N = 7)) in which, for evaluation of hypogonadism (i.e. the absence of one or both testes from the scrotal sac), human chorionic gonadotropin (hCG) tests were performed,We measured IGF-I, total and free testosterone and dehydroepiandrosterone sulfate (DHEAS) by radioimmunoassays before and 48 and 96 h afterthe start of the test. The values of IGF-I were lower (0.001 < p < 0.005) in CGHD and NCGHD than in the other groups. In comparison to basal levels, IGF-I values increased (0.005 < p < 0.05) both 48 and 96h after the start of the hCG test in short idiopathic and normal stature children and in GH-treated subjects with NCGHD, but only 96h in subjects with untreated NCGHD and GH-treated CGHD. No difference was demonstrated in basal values of total testosterone among any of the groups, while basal free testosterone levels were higher (0.001 < p < 0.05) in GH-treated subjects with NCGHD than in all the other groups except nutritional obesity: furthermore, free testosterone was higher ip < 0.05) in nutritional obesity than in CGHD, The values of total and free testosterone obtained both 48 and 96 h after the start of the hCG test were higher (0.001 < p < 0.05) than basal values in all groups. The DHEASvalues did not show any significant change during the hCG test. Basalvalues were higher (0.01 < p < 0.05) in nutritional obesity than in the other groups. Considering all groups, chonological age, bone age and bone age/chronological age ratio were correlated with basal free testosterone, IGF-I and DHEAS levels (0.001 < p < 0.05). while basal freetestosterone and IGF-I values were correlated with DHEAS levels (p < 0.005 and < 0.01, respectively), In conclusion, our study during the hCG test in boys with various clinical conditions demonstrated an increase in IGF-I concentrations only in those boys with sufficient GH secretion or GH replacement therapy, These findings indicate that both sexsteroids and GH are necessary to allow for the pubertal increase in IGF-I levels.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/07/20 alle ore 13:43:34