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Titolo:
EXCRETION OF 2-MONOMETHYL AND 3-MONOMETHYL ETHERS OF 2-HYDROXYESTROGENS IN HEALTHY MALE-VOLUNTEERS
Autore:
BANGER M; HIEMKE C; HAUPT M; KNUPPEN R;
Indirizzi:
UNIV ESSEN GESAMTHSCH,DEPT PSYCHIAT,VIRCHOWSTR 174 D-45147 ESSEN GERMANY UNIV MAINZ,DEPT PSYCHIAT MAINZ GERMANY UNIV LUBECK,DEPT BIOCHEM ENDOCRINOL LUBECK GERMANY
Titolo Testata:
European journal of endocrinology
fascicolo: 2, volume: 135, anno: 1996,
pagine: 193 - 197
SICI:
0804-4643(1996)135:2<193:EO2A3E>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
RAT ANTERIOR-PITUITARY; CATECHOL ESTROGENS; HUMAN-URINE; CATECHOLESTROGENS; BINDING; 4-HYDROXYESTRONE; RADIOIMMUNOASSAY; METABOLISM; MECHANISM; LIVER;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
30
Recensione:
Indirizzi per estratti:
Citazione:
M. Banger et al., "EXCRETION OF 2-MONOMETHYL AND 3-MONOMETHYL ETHERS OF 2-HYDROXYESTROGENS IN HEALTHY MALE-VOLUNTEERS", European journal of endocrinology, 135(2), 1996, pp. 193-197

Abstract

The formation of catecholestrogens by 2- and 4-hydroxylation of monophenolic estrogens represents a major route of estrogen metabolism, In vitro and in vivo studies on catecholestrogens have shown that 2-hydroxylated catecholestrogens are primarily inactivated by O-methylation, while O-methylation of l-hydroxylated estro en is of minor importance. In the present study the in vivo production of isomeric 2- and 3-monomethyl ethers of 2-hydroxyestrogens was measured in 12 healthy omnivorous male volunteers aged 51 +/- 4 years. The sum of estrone and 17 beta-estradiol, 2-hydroxyestrogens (sum of 2-hydroxyestrone and 2-hydroxyestradiol), 4-hydroxyestrogens (sum of 4-hydroxyestrone and 4-hydroxyestradiol) and the sum of the isomeric monomethyl ethers of 2-hydroxyestrone and 2-hydroxyestradiol were measured in 24-h urinary samples. The determinations included hydrolysis of steroid conjugates, separationby chromatographic steps and final quantification by radioimmunoassay. The specificity of the antibodies enabled differentiation between the isomeric monomethyl ethers. The mean urinary excretion rates were 8.8 +/- 2.9 mu g/24h for estrone plus estradiol, 5.2 +/- 2.4 mu g/24 h for the 2-hydroxyestrogens and 1.3 +/- 0.5 mu g/24 h for the 4-hydroxyestrogens, The 2- and 3-monomethyl ethers of the 2-hydroxyestrogens were found in all individuals, with excretion rates of 5.8 +/- 2.6 mu g/24 h for 2-methoxyestrogens and 3.6 +/- 1.1 mu g/24 h for 2-hydroxyestrogen-3-methyl ethers. The findings indicated that 2-hydroxyestradiol is metabolized in vivo by 2-O-methylation and, to a lesser extent, by 3-O-methylation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 20:07:12