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Titolo:
REGULATION OF THE INVASION SUPPRESSOR FUNCTION OF THE CADHERIN CATENIN COMPLEX/
Autore:
VERMEULEN S; VANMARCK V; VANHOORDE L; VANROY F; BRACKE M; MAREEL M;
Indirizzi:
STATE UNIV GHENT HOSP,DEPT RADIOTHERAPY & NUCL MED,EXPT CANCEROL LAB,PINTELAAN 185 B-9000 GHENT BELGIUM STATE UNIV GHENT HOSP,DEPT RADIOTHERAPY & NUCL MED,EXPT CANCEROL LAB B-9000 GHENT BELGIUM STATE UNIV GHENT,MOL CELL BIOL LAB B-9000 GHENT BELGIUM
Titolo Testata:
Pathology research and practice
fascicolo: 7, volume: 192, anno: 1996,
pagine: 694 - 707
SICI:
0344-0338(1996)192:7<694:ROTISF>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
CELL-CELL-ADHESION; EPIDERMAL GROWTH-FACTOR; BREAST-CANCER-CELLS; MOLECULE E-CADHERIN; TYROSINE KINASE SUBSTRATE; ALPHA-CATENIN EXPRESSION; MAMMARY EPITHELIAL-CELLS; HUMAN CARCINOMA-CELLS; BETA-CATENIN; IN-VITRO;
Keywords:
INVASION; METASTASIS; E-CADHERIN; CATENINS; IGF-1; TAMOXIFEN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
97
Recensione:
Indirizzi per estratti:
Citazione:
S. Vermeulen et al., "REGULATION OF THE INVASION SUPPRESSOR FUNCTION OF THE CADHERIN CATENIN COMPLEX/", Pathology research and practice, 192(7), 1996, pp. 694-707

Abstract

Invasion is the cause of cancer malignancy. Invasion results from thecross-talk between cancer cells and host cells, building molecular invasion-promoter and invasion-suppressor complexes. The E-cadherin/catenin invasion-suppressor complex is regulated multifactorially, at multiple levels and sometimes in a reversible way. Mutations in the E-cadherin gene combined with loss of the wild type allele, causing irreversible downregulation, has been demonstrated only in a minority of humancancers. Posttranslational and reversible downregulation has been ascribed to tyrosine phosphorylation of beta-catenin. Phosphorylation is also implicated in transmembrane receptor signal transduction through the E-cadherin/catenin complex. E-cadherin interacts with E-cadherin on another cell through a dimeric adhesion zipper, involving the histidine-alanine-valine (HAV) sequence of the first extracellular domains. This is the major extracellular link of the E-cadherin/catenin complex, though not the only one. Intracellularly, the list of proteins that bind to or signal through the complex or through one or more of its elements is steadily growing. Extrinsic factors may influence the complex. At least in vitro, insulin-like growth factor-I, retinoic acid, tangeretin and tamoxifen were shown to upregulate the functions of the E-cadherin/catenin complex including inhibition of invasion.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/07/20 alle ore 01:41:42