Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
TYPE-I COLLAGEN AND PROCOLLAGEN FRAGMENTS IN PATIENTS WITH METABOLIC BONE-DISEASES
Autore:
LIN JS; KAO JT; TSAI KS;
Indirizzi:
NATL TAIWAN UNIV HOSP,DEPT LAB MED,COLL MED,DIV CLIN BIOCHEM,7 CHUNG SHAN S RD TAIPEI TAIWAN NATL TAIWAN UNIV HOSP,DEPT LAB MED,COLL MED,DIV CLIN BIOCHEM TAIPEI TAIWAN NATL TAIWAN UNIV,COLL MED,SCH MED TECHNOL TAIPEI 10764 TAIWAN NATL TAIWAN UNIV HOSP,DEPT INTERNAL MED,COLL MED TAIPEI 100 TAIWAN
Titolo Testata:
Journal of the Formosan Medical Association
fascicolo: 7, volume: 95, anno: 1996,
pagine: 523 - 529
SICI:
0929-6646(1996)95:7<523:TCAPFI>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
PYRIDINIUM CROSS-LINKS; PRIMARY HYPERPARATHYROIDISM; BIOCHEMICAL MARKERS; TERMINAL PROPEPTIDE; URINARY-EXCRETION; PYRIDINOLINE; RADIOIMMUNOASSAY; DEGRADATION; RESORPTION; TURNOVER;
Keywords:
PROCOLLAGEN TYPE 1; HYPERCALCEMIA; MALIGNANCY; HYPERTHYROIDISM; HYPERPARATHYROIDISM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
36
Recensione:
Indirizzi per estratti:
Citazione:
J.S. Lin et al., "TYPE-I COLLAGEN AND PROCOLLAGEN FRAGMENTS IN PATIENTS WITH METABOLIC BONE-DISEASES", Journal of the Formosan Medical Association, 95(7), 1996, pp. 523-529

Abstract

The purpose of the present study was to evaluate the serum levels of two new markers, and to compare their clinical usefulness with two conventional markers. Healthy women and patients with aberrant bone metabolism were evaluated for serum or urine levels of different bone markers. We measured serum levels of the pyridinoline cross-linked telopeptide domain of type 1 collagen (S-ICTP) and carboxy-terminal propeptideof type 1 procollagen (S-PICP) as markers of bone resorption and formation, respectively. These levels were compared to the concentrations of serum bone gamma-carboxyglutamic acid protein (S-BGP) and total urinary pyridinium cross-links (U-PYD). The control group included 222 premenopausal and postmenopausal women, and the disease groups consistedof 61 individuals with malignancy-associated hypercalcemia, Graves' thyrotoxicosis or primary hyperparathyroidism. Both S-PICP and S-BGP reflected higher bone turnover in postmenopausal than premenopausal women. All patient groups had significantly higher S-ICTP and U-PYD than the controls. Increased S-PICP was seen in malignancy-associated hypercalcemia and Graves' thyrotoxicosis, but not in primary hyperparathyroidism, while higher S-BGP was seen in Graves' thyrotoxicosis and primary hyperparathyroidism, but not in malignancy-associate hypercalcemia. Discrepancy between S-PICP and S-BGP in malignancy-associated hypercalcemia and primary hyperparathyroidism was noted. S-ICTP and U-PYD had higher sensitivity and specificity in discriminating patients from controls. We conclude that S-ICTP is superior to U-PYD as an index of bone resorption in aberrant bone metabolism. S-PICP may also be a useful bone turnover marker but discrepancies between it and S-BGP in malignancy-associated hypercalcemia and primary hyperparathyroidism need further investigation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 01:14:06