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Titolo:
UPTAKE OF 7,12-DIMETHYLBENZ(A)ANTHRACENE AND BENZO(A)PYRENE IN MELANIN-CONTAINING TISSUES
Autore:
ROBERTO A; LARSSON BS; TJALVE H;
Indirizzi:
UPPSALA UNIV,BIOMED CTR,DEPT PHARMACEUT SCI,BOX 594 S-75124 UPPSALA SWEDEN UPPSALA UNIV,DEPT PHARMACEUT BIOSCI,DIV TOXICOL,BMC S-75124 UPPSALA SWEDEN SWEDISH UNIV AGR SCI,CTR BIOMED,DEPT PHARMACOL & TOXICOL S-75123 UPPSALA SWEDEN
Titolo Testata:
Pharmacology & toxicology
fascicolo: 2, volume: 79, anno: 1996,
pagine: 92 - 99
SICI:
0901-9928(1996)79:2<92:UO7ABI>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
CUTANEOUS MALIGNANT-MELANOMA; POLYVINYL-CHLORIDE WORKERS; SKIN MELANOMA; CANCER INCIDENCE; VINYL-CHLORIDE; MICE; MORTALITY; METABOLISM; INDUSTRY; TUMORS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
53
Recensione:
Indirizzi per estratti:
Citazione:
A. Roberto et al., "UPTAKE OF 7,12-DIMETHYLBENZ(A)ANTHRACENE AND BENZO(A)PYRENE IN MELANIN-CONTAINING TISSUES", Pharmacology & toxicology, 79(2), 1996, pp. 92-99

Abstract

It is widely accepted that UV exposure is the main etiological factorfor malignant melanoma. Epidemiologic studies, however, have indicated that also chemical carcinogens may be a risk factor for the disease. Polycyclic aromatic hydrocarbons such as 7,12-dimethylbenz(a)anthracene and benzo(a)pyrene represent an important class of carcinogenic chemicals. It is known that 7,12-dimethylbenz(a)anthracene can induce melanotic tumours in various animal species, and human melanocytes in culture have been found to be capable of metabolizing benzo(a)pyrene to its proximate carcinogen benzo(a)pyrene-7,8-diol. In the present study the disposition of C-14- and H-3-7, 12-dimethylbenz(a)anthracene and C-14-benzo(a)pyrene was studied in pigmented and albino mice and Syriangolden hamsters by whole-body autoradiography. The results showed pronounced retention of label in the melanin-containing structures of theeyes and the hair follicles in the pigmented animals. The labelling of the corresponding structures in the albino animals was low. Additional experiments showed that 7,12-dimethylbenz(a)anthracene and benzo(a)pyrene as well as some of their metabolites are bound to melanin in vitro. The specific localization of the polycyclic aromatic hydrocarbonsin pigmented tissues due to melanin affinity, combined with bioactivating capacity of melanocytes, suggest that these substances may play arole in the induction of malignant melanoma.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 19:14:10