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Titolo:
DETECTION OF HUMAN HERPES-VIRUS-6 IN AIDS-ASSOCIATED RETINITIS BY MEANS OF IN-SITU HYBRIDIZATION, POLYMERASE CHAIN-REACTION AND IMMUNOHISTOCHEMISTRY
Autore:
FILLET AM; REUX I; JOBERTY C; FOURNIER JG; HAUW JJ; HOANG PL; BRICAIRE F; HURAUX JM; AGUT H;
Indirizzi:
GRP HOSP PITIE SALPETRIERE,CERVI,VIROL LAB,47-83 BD HOP F-75651 PARIS13 FRANCE GRP HOSP PITIE SALPETRIERE,CNRS EP57,LAB BACTERIOL VIROL F-75651 PARIS 13 FRANCE GRP HOSP PITIE SALPETRIERE,DEPT OPHTHALMOL F-75651 PARIS 13 FRANCE GRP HOSP PITIE SALPETRIERE,NEUROPATHOL LAB F-75651 PARIS 13 FRANCE GRP HOSP PITIE SALPETRIERE,DEPT INFECT DIS F-75651 PARIS 13 FRANCE HOP ST VINCENT DE PAUL,INSERM U43 F-75674 PARIS FRANCE
Titolo Testata:
Journal of medical virology
fascicolo: 4, volume: 49, anno: 1996,
pagine: 289 - 295
SICI:
0146-6615(1996)49:4<289:DOHHIA>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN HERPESVIRUS-6 INFECTION; IMMUNE-DEFICIENCY SYNDROME; ACQUIRED-IMMUNODEFICIENCY-SYNDROME; EXANTHEM-SUBITUM; OCULAR MANIFESTATIONS; CHILDREN; HHV-6; HIV-1; DNA; COMPLICATIONS;
Keywords:
HHV-6; RETINITIS; HIV-1; CMV; AIDS; PCR; IN SITU HYBRIDIZATION; IMMUNOHISTOCHEMISTRY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
40
Recensione:
Indirizzi per estratti:
Citazione:
A.M. Fillet et al., "DETECTION OF HUMAN HERPES-VIRUS-6 IN AIDS-ASSOCIATED RETINITIS BY MEANS OF IN-SITU HYBRIDIZATION, POLYMERASE CHAIN-REACTION AND IMMUNOHISTOCHEMISTRY", Journal of medical virology, 49(4), 1996, pp. 289-295

Abstract

The ubiquitous nature of HHV-6 and its genomic relationship with cytomegalovirus led us to evaluate an etiological link between HHV-6 and AIDS-associated retinitis in a prospective study. HHV-6 infection was studied in patients with AIDS-associated retinitis and in two control populations. Eye pairs were obtained at necropsy from nine patients with AIDS-associated retinitis, four human immunodeficiency virus (HIV)-seropositive patients with normal fundus examination and three HIV-seronegative patients. HHV-6 infection was detected by polymerase chain reaction (PCR), in situ hybridization and immunohistochemistry. Human cytomegalovirus (CMV) and HIV-1 infections were detected in parallel by the same methods. HHV-6 infection was detected in three cases of AIDS-associated retinitis. In two of these patients, HHV-6 infection was detected both by immunohistochemistry and PCR while in the third case itwas detected by in situ hybridization and PCR. In the three patients,fundus examination showed bilateral retinitis in two of them and unilateral retinitis in one of them. HHV-6 infection was not detected in the retina of the two control groups. CMV was also detected in the three cases positive for HHV-6 by all three methods. HIV DNA was detected by PCR in two of th ree cases and was confirmed in one of these cases by in situ hybridization. These results confirm that HHV-6 infects theretina but suggests that HHV-6 does not have an exclusive causative role in AIDS-associated retinitis, since CMV coinfection of the retina was detected in all three of the patients positive for HHV-6. (C) 1996Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 09:35:59