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Titolo:
THE TREATMENT OF ALCOHOLIC HEPATITIS
Autore:
MORGAN MY;
Indirizzi:
ROYAL FREE HOSP,DEPT MED,POND ST LONDON NW3 2QG ENGLAND
Titolo Testata:
Alcohol and alcoholism
fascicolo: 2, volume: 31, anno: 1996,
pagine: 117 - 134
SICI:
0735-0414(1996)31:2<117:TTOAH>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
ORTHOTOPIC LIVER-TRANSPLANTATION; RANDOMIZED CLINICAL-TRIAL; DOUBLE-BLIND TRIAL; CORTICOSTEROIDS REDUCE MORTALITY; AMINO-ACID SUPPLEMENTATION; SHORT-TERM; PARENTERAL-NUTRITION; GLUCAGON-INFUSION; METHYLPREDNISOLONE THERAPY; HYPERMETABOLIC STATE;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
100
Recensione:
Indirizzi per estratti:
Citazione:
M.Y. Morgan, "THE TREATMENT OF ALCOHOLIC HEPATITIS", Alcohol and alcoholism, 31(2), 1996, pp. 117-134

Abstract

Alcoholic hepatitis is a precirrhotic lesion; it develops in only a minority of chronic alcohol abusers even alter decades of abuse. The clinical spectrum of disease varies from asymptomatic hepatomegaly to florid hepatocellular failure with gastrointestinal bleeding and hepaticencephalopathy. Corresponding variation is observed both in morbidityand mortality. The majority of individuals with mild to moderate alcoholic hepatitis improve significantly following abstinence from alcohol and the provision of a diet sufficient to meet their nutritional requirements; their long-term outcome is determined largely by their ability to maintain abstinence from alcohol. Individuals with severe alcoholic hepatitis require intensive nutritional support and vigorous management of the complications of their liver injury: their outcome is generally poor. A small. carefully selected subgroup, of these very sickpatients may benefit. at least in the short-term. from treatment withcorticosteroids: the place of orthotopic hepatic transplantation, in this patient group, is still the subject of debate. No other treatmentmodalities have been shown to confer benefit consistently. A number of new therapeutic approaches have been proposed and need to be explored.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/09/20 alle ore 22:49:28