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Titolo:
PHARMACODYNAMIC EFFECTS OF CIPROFLOXACIN, FLEROXACIN AND LOMEFLOXACININ-VIVO AND IN-VITRO
Autore:
FUENTES F; MARTIN MM; IZQUIERDO J; GOMEZLUS ML; PRIETO J;
Indirizzi:
UNIV COMPLUTENSE,FAC MED,DEPT MICROBIOL,CIUDAD UNIV,AVDA COMPLUTENSE S-N E-28040 MADRID SPAIN UNIV COMPLUTENSE,FAC MED,DEPT MICROBIOL E-28040 MADRID SPAIN
Titolo Testata:
Chemotherapy
fascicolo: 5, volume: 42, anno: 1996,
pagine: 354 - 362
SICI:
0009-3157(1996)42:5<354:PEOCFA>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
SUBINHIBITORY CONCENTRATIONS; ESCHERICHIA-COLI; NEUTROPENIC MICE; THIGH INFECTION; INVIVO; INVITRO; IMIPENEM; MODEL; INTERMITTENT; SPARFLOXACIN;
Keywords:
SUBINHIBITORY CONCENTRATIONS; POSTANTIBIOTIC EFFECT; CIPROFLOXACIN; FLEROXACIN; LOMEFLOXACIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
33
Recensione:
Indirizzi per estratti:
Citazione:
F. Fuentes et al., "PHARMACODYNAMIC EFFECTS OF CIPROFLOXACIN, FLEROXACIN AND LOMEFLOXACININ-VIVO AND IN-VITRO", Chemotherapy, 42(5), 1996, pp. 354-362

Abstract

The present study investigates the postantibiotic effect (PAE) in vivo, and the postantibiotic subinhibitory concentration effects (PA-SE) in vitro and SE in vivo of three 4-fluoroquinolones (ciprofloxacin, fleroxacin and lomefloxacin) against standard strains of Staphylococcus aureus and Escherichia coli. In vivo killing kinetics have also been performed using two different short administrations to study if the PAEduration could cover the time that the antibiotic was below the minimal inhibitory concentration (MIC) in serum. The results show that the three antimicrobial agents induced long PAEs (1.9-3.1 h) against the two microorganisms. Moderate but significant in vitro PA-SEs were also produced (1->9 h). The in vivo SEs were not significant except when the effect of lomefloxacin on E. coli was assayed (0.54 h). Finally, thein vivo killing kinetics showed that the administrations that included the PAE duration were as effective as the schedule that maintained the antibiotic levels in serum above the MIC. Only when fleroxacin and S. aureus were assayed, this last administration was more effective (+0.9 log(10) colony-forming units/thigh).

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/11/20 alle ore 21:33:22