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Titolo:
ORPHANIN FQ NOCICEPTIN-IMMURAOREACTIVE NERVE-FIBERS PARALLEL THOSE CONTAINING ENDOGENOUS OPIOIDS IN RAT SPINAL-CORD/
Autore:
RIEDL M; SHUSTER S; VULCHANOVA L; WANG JL; LOH HH; ELDE R;
Indirizzi:
UNIV MINNESOTA,DEPT CELL BIOL & NEUROANAT,321 CHURCH ST SE MINNEAPOLIS MN 55455 UNIV MINNESOTA,DEPT PHARMACOL MINNEAPOLIS MN 55455
Titolo Testata:
NeuroReport
fascicolo: 8, volume: 7, anno: 1996,
pagine: 1369 - 1372
SICI:
0959-4965(1996)7:8<1369:OFNNPT>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
RECEPTOR GENE FAMILY; PROTEIN-COUPLED RECEPTOR; DORSAL-ROOT-GANGLIA; MOLECULAR-CLONING; FUNCTIONAL EXPRESSION; IMMUNOREACTIVE DYNORPHIN; REGIONAL DISTRIBUTION; TISSUE DISTRIBUTION; CDNA CLONING; SUBSTANCE-P;
Keywords:
ORPHAN OPIOID RECEPTOR; SPINAL CORD; RAT; DYNORPHIN; ENKEPHALIN; IMMUNOREACTIVITY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
23
Recensione:
Indirizzi per estratti:
Citazione:
M. Riedl et al., "ORPHANIN FQ NOCICEPTIN-IMMURAOREACTIVE NERVE-FIBERS PARALLEL THOSE CONTAINING ENDOGENOUS OPIOIDS IN RAT SPINAL-CORD/", NeuroReport, 7(8), 1996, pp. 1369-1372

Abstract

ANTISERA Were developed that specifically recognize orphanin FQ/nociceptin, the 17 amino acid peptide reported to be the endogenous ligand for the orphan opioid receptor. Immunocytochemical localizations in rat spinal cord demonstrated that orphanin FQ /nociceptin-immunoreactivity (-ir) was abundant in superficial dorsal horn, lateral spinal nucleus and the region dorsal to the central canal, areas that also exhibitprominent enkephalin- and dynorphin-ir. Orphanin FQ/nociceptin-ir wasnot affected by dorsal rhizotomy, indicating that in spinal cord the peptide is produced by central rather than primary afferent neurons. Thus, the distribution of orphanin FQ/nociceptin-ir appeared in neuronal circuits that parallel those containing enkephalin- and dynorphin-ir, with only modest co-existence of these peptides.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 16/07/20 alle ore 04:25:03