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Titolo:
PREGNANCY AND THE RISK OF STROKE
Autore:
KITTNER SJ; STERN BJ; FEESER BR; HEBEL JR; NAGEY DA; BUCHHOLZ DW; EARLEY CJ; JOHNSON CJ; MACKO RF; SLOAN MA; WITYK RJ; WOZNIAK MA;
Indirizzi:
UNIV MARYLAND,DEPT NEUROL,BRESSLER BLDG,RM 12-013,655 W BALTIMORE ST BALTIMORE MD 21201 UNIV MARYLAND,DEPT EPIDEMIOL & PREVENT MED BALTIMORE MD 21201 UNIV MARYLAND,DEPT OBSTET & GYNECOL BALTIMORE MD 21201 JOHNS HOPKINS UNIV,DEPT NEUROL BALTIMORE MD 21218 SINAI HOSP,DIV NEUROL BALTIMORE MD 21215 EMORY UNIV,DEPT NEUROL ATLANTA GA 30322
Titolo Testata:
The New England journal of medicine
fascicolo: 11, volume: 335, anno: 1996,
pagine: 768 - 774
SICI:
0028-4793(1996)335:11<768:PATROS>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
PUERPERIUM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
32
Recensione:
Indirizzi per estratti:
Citazione:
S.J. Kittner et al., "PREGNANCY AND THE RISK OF STROKE", The New England journal of medicine, 335(11), 1996, pp. 768-774

Abstract

Background It is widely believed that pregnancy increases the risk ofstroke, but there are few data available to quantify that risk. Methods We identified all female patients 15 through 44 years of age in central Maryland and Washington, D.C., who were discharged from any of 46hospitals in the study area in 1988 or 1991. Two neurologists reviewed each case, using data from the women's medical records. We determined whether the women had been pregnant at the time of the stroke or up to six weeks before it occurred. For purposes of this analysis, the six-week period after pregnancy could begin with an induced or spontaneous abortion or with the delivery of a live or stillborn child. ResultsSeventeen cerebral infarctions and 14 intracerebral hemorrhages occurred in women who were or had recently been pregnant (pregnancy-relatedstrokes), and there were 175 cerebral infarctions and 48 intracerebral hemorrhages that were not related to pregnancy. For cerebral infarction, the relative risk during pregnancy, adjusted for age and race, was 0.7 (95 percent confidence interval, 0.3 to 1.6), but it increased to 8.7 for the postpartum period (after a live birth or stillbirth) (95percent confidence interval, 4.6 to 16.7). For intracerebral hemorrhage, the adjusted relative risk was 2.5 during pregnancy (95 percent confidence interval, 1.0 to 6.4) but 28.3 for the postpartum period (95 percent confidence interval, 13.0 to 61.4). Overall, for either type of stroke during or within six weeks after pregnancy, the adjusted relative risk was 2.4 (95 percent confidence interval, 1.6 to 3.6), and the attributable, or excess, risk was 8.1 strokes per 100,000 pregnancies (95 percent confidence interval, 6.4 to 9.7). Conclusions The risks of both cerebral infarction and intracerebral hemorrhage are increasedin the six weeks after delivery but nor during pregnancy itself. (C) 1996, Massachusetts Medical Society.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 20:01:58