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Titolo:
SIMILAR DECREASE IN SPONTANEOUS MORPHINE ABSTINENCE BY METHADONE AND RB-101, AN INHIBITOR OF ENKEPHALIN CATABOLISM
Autore:
RUIZ F; FOURNIEZALUSKI MC; ROQUES BP; MALDONADO R;
Indirizzi:
UNIV PARIS 05,FAC SCI PHARMACEUT & BIOL,URA D CNRS 1500,INSERM U266,UNITE PHARMACOCHIM MOL F-75270 PARIS 06 FRANCE UNIV PARIS 05,FAC SCI PHARMACEUT & BIOL,URA D CNRS 1500,INSERM U266,UNITE PHARMACOCHIM MOL F-75270 PARIS 06 FRANCE
Titolo Testata:
British Journal of Pharmacology
fascicolo: 1, volume: 119, anno: 1996,
pagine: 174 - 182
SICI:
0007-1188(1996)119:1<174:SDISMA>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
NALOXONE-INDUCED WITHDRAWAL; B RECEPTOR ANTAGONISTS; RAT LOCUS COERULEUS; DEGRADING ENZYMES; ENDOGENOUS ENKEPHALINS; SPINAL-CORD; REGULATORY MECHANISMS; OPIOID RECEPTORS; DEPENDENT RATS; TREATED RATS;
Keywords:
SPONTANEOUS MORPHINE WITHDRAWAL; RB 101; METHADONE; ENDOGENOUS ENKEPHALINS; CLONIDINE; PD-134,308; CCKB RECEPTORS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
64
Recensione:
Indirizzi per estratti:
Citazione:
F. Ruiz et al., "SIMILAR DECREASE IN SPONTANEOUS MORPHINE ABSTINENCE BY METHADONE AND RB-101, AN INHIBITOR OF ENKEPHALIN CATABOLISM", British Journal of Pharmacology, 119(1), 1996, pp. 174-182

Abstract

1 The dual inhibitor of enkephalin degrading enzymes, RB 101, is ableto block endogenous enkephalin metabolism completely, leading to potent antinociceptive responses potentiated by blockade of CCKB receptors. In this study we have investigated the effects induced by RB 101 given alone, or with the CCKB antagonist, PD-134,308, on a model of spontaneous morphine withdrawal and substitutive maintenance in rats. 2 Animals were chronically treated with morphine for 7 days followed, 36 h after the interruption of drug administration, by a maintenance treatment for 5 days with methadone (2 mg kg(-1), i.p.), clonidine (0.025 mgkg(-1), i.p.), RB 101 (40 mg kg(-1), i.p.), PD-134,308 (3 mg kg(-1), i.p.) or a combination of RB 101 plus PD-134,308. Several behavioural observations were made during this period in order to evaluate the acute effects as well as the consequence of chronic maintenance induced on spontaneous withdrawal by the different treatments. 3 Methadone was the most effective compound in decreasing the spontaneous withdrawal syndrome after acute administration. Both, methadone and RB 101 had similar effectiveness in reducing opiate abstinence during the period of substitutive treatment. PD-134,308 did not show any effect when administered alone and did not modify the effect of RB 101. 4 Naloxone (1 mgkg(-1), s.c.) failed to precipitate any sign of withdrawal when injected at the end of the chronic maintenance treatment suggesting that, under the present conditions, methadone and RB 101 did not induce significant physical opiate-dependence. 5 The mildness of the side effects induced by chronic RB 101, suggests that systemically active inhibitors of enkephalin catabolism could represent a promising treatment in the maintenance of opiate addicts.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/03/20 alle ore 00:49:07