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Titolo:
CURRENT ESTROGEN-PROGESTIN AND ESTROGEN REPLACEMENT THERAPY IN ELDERLY WOMEN - ASSOCIATION WITH CAROTID ATHEROSCLEROSIS
Autore:
JONAS HA; KRONMAL RA; PSATY BM; MANOLIO TA; MEILAHN EN; TELL GS; TRACY RP; ROBBINS JA; ANTONCULVER H;
Indirizzi:
LA TROBE UNIV,CTR STUDY MOTHER & CHILDRENS HLTH,463 CARDIGAN ST CARLTON VIC 3053 AUSTRALIA LA TROBE UNIV,CTR STUDY MOTHERS & CHILDRENS HLTH MELBOURNE VIC AUSTRALIA UNIV WASHINGTON,DEPT BIOSTAT SEATTLE WA 98195 UNIV WASHINGTON,DEPT MED SEATTLE WA 98195 UNIV WASHINGTON,DEPT EPIDEMIOL SEATTLE WA 98195 UNIV WASHINGTON,DEPT HLTH SERV SEATTLE WA 98195 NHLBI,DIV EPIDEMIOL & CLIN APPLICAT BETHESDA MD 20892 WAKE FOREST UNIV,BOWMAN GRAY SCH MED,DEPT PUBL HLTH SCI WINSTON SALEMNC 27103 UNIV LONDON LONDON SCH HYG & TROP MED,DEPT EPIDEMIOL LONDON WC1E 7HT ENGLAND UNIV VERMONT,DEPT PATHOL BURLINGTON VT 05405 UNIV CALIF IRVINE,DEPT MED,DIV EPIDEMIOL IRVINE CA 92717 UNIV CALIF DAVIS,DEPT MED SACRAMENTO CA 95817
Titolo Testata:
Annals of epidemiology
fascicolo: 4, volume: 6, anno: 1996,
pagine: 314 - 323
SICI:
1047-2797(1996)6:4<314:CEAERT>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORONARY-ARTERY DISEASE; POSTMENOPAUSAL WOMEN; RISK-FACTORS; CARDIOVASCULAR HEALTH; HEART-DISEASE; MYOCARDIAL-INFARCTION; ENDOMETRIAL CANCER; LIPOPROTEINS; ESTRADIOL; INHIBITION;
Keywords:
ATHEROSCLEROSIS; CAROTID ARTERIAL WALL THICKNESS; CAROTID STENOSIS; ESTROGEN REPLACEMENT THERAPY; COMBINED EXTROGEN/PROGESTIN REPLACEMENT THERAPY; ELDERLY WOMEN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
52
Recensione:
Indirizzi per estratti:
Citazione:
H.A. Jonas et al., "CURRENT ESTROGEN-PROGESTIN AND ESTROGEN REPLACEMENT THERAPY IN ELDERLY WOMEN - ASSOCIATION WITH CAROTID ATHEROSCLEROSIS", Annals of epidemiology, 6(4), 1996, pp. 314-323

Abstract

The cardioprotective effects of combined estrogen/progestin replacement therapy have been questioned. Therefore, we have compared carotid arterial wall thickening and the prevalence of carotid stenosis in elderly women (greater than or equal to 65 years old) currently using replacement estrogen/progestins (E+P) with arterial pathology and its prevalence in women using unopposed estrogens (E). This cross-sectional study used baseline data from all 2962 women participating in the Cardiovascular Health Study, a population-based study of coronary heart disease and stroke in elderly adults. Users of hormone replacement therapy(HRT) were categorized as never (n = 1726), past (n = 787), current E(n = 280), or current E+P (n = 73). Maximal intimal-medial thicknesses of the internal and common carotid arteries and stenosis of the internal carotid arteries were measured by ultrasonography. Current E+P users resembled current E users in most respects, although some lifestyle factors were more favorable among E+P users. Current ESP use and current E use (as compared with no use) were associated with smaller internal carotid wall thicknesses (-0.22 mm; P = 0.003; and -0.09 mm; P = 0.05, respectively) and smaller common carotid wall thicknesses (-0.05mm; P = 0.03; and -0.02 mm; P = 0.1, respectively) and lower odds ratios (OR) for carotid stenosis (greater than or equal to 1% vs. 0%); OR= 0.61; 95% confidence interval [CI]: 0.36 to 1.01; and OR = 0.91, 95% CI: 0.67 to 1.24, respectively, after adjustment for current lifestyle and risk factors. When both groups of current HRT users were compared, there were no significant differences in carotid wall thicknesses or prevalence of carotid stenosis. For this sample of elderly women, both current E+P therapy and current E therapy were associated with decreased measures of carotid atherosclerosis. These measures did not differ significantly between the two groups of HRT users. Ann Epidemiol 1996; 6:314-323.

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Documento generato il 05/12/20 alle ore 23:50:43