Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
EXPRESSION OF C-FOS, JUN-D AND PP60(C-SRC-RNAS IN THE DEVELOPING AND GRAFTED RAT STRIATUM() MESSENGER)
Autore:
HAQUE NSK; FERNANDEZ JM; MAYER E; HEAVENS RP; DUNNETT SB; SIRINATHSINGHJI DJS;
Indirizzi:
MRC,CAMBRIDGE CTR BRAIN REPAIR,FORVIE SITE,ROBINSON WAY CAMBRIDGE CB22PY ENGLAND MRC,CAMBRIDGE CTR BRAIN REPAIR CAMBRIDGE CB2 2PY ENGLAND UNIV CAMBRIDGE,DEPT EXPT PSYCHOL CAMBRIDGE CB2 2PY ENGLAND MERCK SHARP & DOHME RES LABS,NEUROSCI RES CTR HARLOW CM20 2QR ESSEX ENGLAND
Titolo Testata:
Molecular brain research
fascicolo: 1-2, volume: 41, anno: 1996,
pagine: 90 - 96
SICI:
0169-328X(1996)41:1-2<90:EOCJAP>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
SRC GENE-PRODUCT; MESSENGER-RNA; NERVOUS-SYSTEM; TISSUE GRAFTS; PROTEINS; BRAIN; ONCOGENE; STIMULATION; PP60C-SRC; INDUCTION;
Keywords:
IMMEDIATE EARLY GENE; C-FOS; JUN D; PP60(C-SRC+); HYBRIDIZATION, IN-SITU; STRIATAL LESION; STRIATAL GRAFT; DEVELOPMENT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
40
Recensione:
Indirizzi per estratti:
Citazione:
N.S.K. Haque et al., "EXPRESSION OF C-FOS, JUN-D AND PP60(C-SRC-RNAS IN THE DEVELOPING AND GRAFTED RAT STRIATUM() MESSENGER)", Molecular brain research, 41(1-2), 1996, pp. 90-96

Abstract

Expression of the mRNAs of the proto-oncogenes pp60(c-src+), c-fos and jun D were studied using in-situ hybridisation histochemistry in thedeveloping striatum and in striatal grafts. The temporal patterns of mRNA expression were monitored in the striatum of the normal developing rat from the 12th day of gestation (E12) to 10 days postnatally, andwere compared to the changes in gene expression observed in E13-E14 primordial striatal tissue grafts 7, 15 and 30 days after implantation in the ibotenic acid-lesioned striatum of adult rats. During development, all three proto-oncogenes were most highly expressed just before birth, at E19. Striatal expression of all three was markedly reduced after birth and remained at a low level through to adulthood, A different mode of expression was observed in the transplanted striatum which was unique to each particular gene. jun D and pp60(c-src+) were expressed for a longer time period in the grafted primordial cells than in normal development, whereas no c-fos expression could be detected in thegrafts. These results suggest that transplantation of embryonic neural cells into the host brain may affect the normal developmental regulation of such cells and their expression of some proto-oncogenes.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/07/20 alle ore 19:16:52