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Titolo:
REARING EXPERIENCE AND BIOGENIC-AMINE ACTIVITY IN INFANT RHESUS-MONKEYS
Autore:
CLARKE AS; HEDEKER DR; EBERT MH; SCHMIDT DE; MCKINNEY WT; KRAEMER GW;
Indirizzi:
UNIV WISCONSIN,HARLOW PRIMATE LAB,22 N CHARTER ST MADISON WI 53711 NORTHWESTERN UNIV,SCH MED,ASHER CTR STUDY & TREATMENT DEPRESS DISORDERS CHICAGO IL 60611 UNIV WISCONSIN,DEPT PSYCHIAT MADISON WI 53706 UNIV ILLINOIS,PREVENT RES CTR CHICAGO IL 00000 VANDERBILT UNIV,SCH MED,DEPT PSYCHIAT NASHVILLE TN 00000
Titolo Testata:
Biological psychiatry
fascicolo: 5, volume: 40, anno: 1996,
pagine: 338 - 352
SICI:
0006-3223(1996)40:5<338:REABAI>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
CEREBROSPINAL-FLUID MONOAMINE; LONGITUDINAL PSYCHIATRIC DATA; HPA AXIS ACTIVITY; AFFECTIVE-DISORDERS; SEROTONIN; PRIMATE; STRESS; METABOLITES; DEPRESSION; AGGRESSION;
Keywords:
EARLY EXPERIENCE; NOREPINEPHRINE; 3-METHOXY-4-HYDROXYPHENYLGLYCOL; DIHYDROXYPHENYLACETIC ACID; HOMOVANILLIC ACID; 5-HYDROXYINDOLEACETIC ACID; STRESS RESPONSE; RHESUS MONKEY; CEREBROSPINAL FLUID;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
55
Recensione:
Indirizzi per estratti:
Citazione:
A.S. Clarke et al., "REARING EXPERIENCE AND BIOGENIC-AMINE ACTIVITY IN INFANT RHESUS-MONKEYS", Biological psychiatry, 40(5), 1996, pp. 338-352

Abstract

In this report we present evidence that early social experience influences aspects of the function of brain biogenic amine systems most notably the noradrenergic system. Biogenic amine activity was studied in mother- vs. peer-reared monkey infants over the first 6 months of lifeand in response to two housing transitions, Norepinephrine (NE), 3-methoxy-4-hydroxyphenylglycol (MHPG), dihydroxyphenylacetic acid (DOPAC), homovanillic acid (HVA), ann 5-hydroxyindoleacetic acid (5-HLAA) levels in cerebrospinal fluid (CSF) were measured Peer-reared monkeys showed significantly higher CSF levels of norepinephrine and MHPG than mother-reared animals over early development, but showed an attentuated NE response to separation and group formation compared to mother-reared animals. Peer-reared monkeys showed a greater developmental decline in 5-HIAA levels than mother-reared monkeys. There were no rearing effects for DOPAC or HVA over early development; however, peer-reared monkeys showed significantly lower HVA and DOPAC concentrations at 6-8 months of age, The results add to evidence for the influence of primate mothers on the psychobiological development of central nervous system neurotransmitter systems in their infants, and suggest that the noradrenergic system is among the more sensitive of these to early experience.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 10:19:15