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Titolo:
COMPARABLE AMYLOID BETA-PROTEIN (A-BETA)-42(43) AND A-BETA-40 DEPOSITION IN THE AGED MONKEY BRAIN
Autore:
KANEMARU K; IWATSUBO T; IHARA Y;
Indirizzi:
TOKYO METROPOLITAN GERIATR HOSP,DEPT NEUROL,ITABASHI KU,35-2 SAKAE CHO TOKYO 173 JAPAN UNIV TOKYO,FAC PHARMACEUT SCI,DEPT NEUROPATHOL & NEUROSCI TOKYO 113 JAPAN UNIV TOKYO,INST BRAIN RES,DEPT NEUROPATHOL TOKYO JAPAN
Titolo Testata:
Neuroscience letters
fascicolo: 2-3, volume: 214, anno: 1996,
pagine: 196 - 198
SICI:
0304-3940(1996)214:2-3<196:CAB(AA>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
ALZHEIMERS-DISEASE; SENILE PLAQUES;
Keywords:
AMYLOID BETA-PROTEIN; AGED MONKEY BRAIN; ALZHEIMERS DISEASE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
18
Recensione:
Indirizzi per estratti:
Citazione:
K. Kanemaru et al., "COMPARABLE AMYLOID BETA-PROTEIN (A-BETA)-42(43) AND A-BETA-40 DEPOSITION IN THE AGED MONKEY BRAIN", Neuroscience letters, 214(2-3), 1996, pp. 196-198

Abstract

Two distinct species of amyloid beta-protein (A beta), A beta 42(43) and A beta 40, are deposited in the brains of patients with Alzheimer's disease and normal aged individuals. A beta 42(43), the long tailed A beta, is the initially and predominantly deposited species in senileplaques. Deposition of A beta is also observed in the aged monkey brains. We investigated the A beta species in the aged monkey brains immunocytochemically using monoclonal antibodies that discriminate betweenthe C-termini of A beta 42(43) and A beta 40. We report here that A beta 40 as well as A beta 42(43) deposit in various types of senile plaques, including diffuse plaques of the aged monkey brain and that the ratio of A beta 40 to A beta 42(43) is higher compared with that in human brain.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 02:42:21