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Titolo:
SHORT-TERM PREDICTORS OF INCIDENT STROKE IN OLDER ADULTS - THE CARDIOVASCULAR HEALTH STUDY
Autore:
MANOLIO TA; KRONMAL RA; BURKE GL; OLEARY DH; PRICE TR;
Indirizzi:
NHLBI,DIV EPIDEMIOL & CLIN APPLICAT,6701 ROCKLEDGE DR,RM 8160 BETHESDA MD 20892 UNIV WASHINGTON,DEPT BIOSTAT SEATTLE WA 98195 WAKE FOREST UNIV,BOWMAN GRAY SCH MED,DEPT PUBL HLTH SCI WINSTON SALEMNC 27103 TUFTS NEW ENGLAND MED CTR,DEPT RADIOL BOSTON MA 00000 UNIV MARYLAND,DEPT NEUROL BALTIMORE MD 21201
Titolo Testata:
Stroke
fascicolo: 9, volume: 27, anno: 1996,
pagine: 1479 - 1486
SICI:
0039-2499(1996)27:9<1479:SPOISI>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORONARY HEART-DISEASE; RISK-FACTORS; MEN; MORTALITY; COMMUNITY; COHORT; AGE;
Keywords:
AGED; STROKE, CEREBROVASCULAR DISORDERS; EPIDEMIOLOGY; RISK FACTORS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
47
Recensione:
Indirizzi per estratti:
Citazione:
T.A. Manolio et al., "SHORT-TERM PREDICTORS OF INCIDENT STROKE IN OLDER ADULTS - THE CARDIOVASCULAR HEALTH STUDY", Stroke, 27(9), 1996, pp. 1479-1486

Abstract

Background and Purpose Risk factors for incident stroke have been examined in middle-aged persons, but less is known about stroke precursors in the elderly, who suffer the highest rates of stroke. Short-term risk factors for incident stroke were examined in a longitudinal, population-based study including extensive measures of subclinical disease. Methods Prospective study of 5201 women and men aged 65 years and older was undertaken in the multicenter Cardiovascular Health Study. Results During an average 3.31-year follow-up, 188 incident strokes occurred. Stroke incidence increased significantly with age and was similar in women and men. Factors associated with increased stroke risk in multivariate analysis included age, aspirin use, diabetes, impaired glucose tolerance, higher systolic blood pressure, increased time needed towalk 15 ft, frequent falls, elevated creatinine level, abnormal left ventricular (LV) wall motion and increased LV mass on echocardiography, ultrasound-defined carotid stenosis, and atrial fibrillation. Increased LV mass and carotid stenosis were associated with twofold and threefold increases in incidences of stroke, respectively (P<.001). Aspirin users had a 52% higher risk of stroke (relative risk, 1.52; 95% confidence interval, 1.1 to 2.0; P<.007) after adjustment for other factors. This association was present only among aspirin users without priorcoronary disease, atrial fibrillation, claudication, or transient ischemic attack, who had an 84% higher risk (relative risk, 1.84; 95% confidence interval, 1.2 to 2.8). Conclusions Short-term risk of stroke has a complex relationship with aspirin use and is strongly related to subclinical disease in this sample of older adults. These relationships should be considered in assessing stroke risk in the elderly, in whom recognized and subclinical cardiovascular disease is highly prevalent.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 15:41:31