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Titolo:
ION-PAIR ADSORPTION CHROMATOGRAPHY FOR PROCESS PURPOSES - BASIC EQUILIBRIUM STUDIES FOR THE RECOVERY OF CLAVULANIC ACID BY USING QUATERNARYAMMONIUM-SALTS
Autore:
MAYER AF; DECKWER WD;
Indirizzi:
GESELL BIOTECHNOL FORSCH MBH,DIV BIOCHEM ENGN,MASCHERODER WEG 1 D-38124 BRAUNSCHWEIG GERMANY GESELL BIOTECHNOL FORSCH MBH,DIV BIOCHEM ENGN D-38124 BRAUNSCHWEIG GERMANY
Titolo Testata:
Journal of chromatography
fascicolo: 2, volume: 741, anno: 1996,
pagine: 185 - 203
Fonte:
ISI
Lingua:
ENG
Soggetto:
LIQUID-CHROMATOGRAPHY; ELECTROSTATIC THEORY; PEAK COMPRESSION; SYSTEM PEAKS; MODEL; OPTIMIZATION; RETENTION;
Keywords:
ION-PAIRING REAGENTS; PREPARATIVE CHROMATOGRAPHY; ADSORPTION ISOTHERMS; THERMODYNAMIC PARAMETERS; CLAVULANIC ACID; QUATERNARY AMMONIUM COMPOUNDS; CHARCOAL, ACTIVATED; AMBERLITE XAD;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
19
Recensione:
Indirizzi per estratti:
Citazione:
A.F. Mayer e W.D. Deckwer, "ION-PAIR ADSORPTION CHROMATOGRAPHY FOR PROCESS PURPOSES - BASIC EQUILIBRIUM STUDIES FOR THE RECOVERY OF CLAVULANIC ACID BY USING QUATERNARYAMMONIUM-SALTS", Journal of chromatography, 741(2), 1996, pp. 185-203

Abstract

Ion-pair adsorption chromatography was used to purify clavulanic acid(CA) by employing commercial hydrophobic matrixes in combination withquaternary ammonium salts (QAS). To understand the mechanism governing the interactions between CA, QAS and the matrix, batch experiments were done where the equilibrium relationships for the combinations CA-matrix, QAS-matrix and CA-QAS-matrix were individually investigated. Itwas shown that the presence of CA can cause a significant concentration-dependent shift in the loading of QAS on the matrix. At high CA concentrations, the total capacity of the system is higher than that expected from a mechanism based purely on ion-pair interactions. These phenomena were analysed qualitatively and semi-quantitatively from the viewpoint of the electrostatic theory and of chemical equilibrium relations between the different species involved in the system. It could be shown that, at the normal conditions used in preparative chromatography, the interactions between CA and the matrix and between CA and QAS in the liquid phase cannot be neglected and have an important contribution to the capacity and affinity of the stationary phase for the adsorbate.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 22:28:00