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Titolo:
EFFECTS OF 2 INJECTABLE ANESTHETIC AGENTS ON COAGULATION ASSAYS IN THE RAT
Autore:
STRINGER SK; SELIGMANN BE;
Indirizzi:
UNIV ARIZONA,ARIZONA HLTH SCI CTR,DEPT SURG TUCSON AZ 85724 HOECHST MARION ROUSSEL CINCINNATI OH 00000
Titolo Testata:
Laboratory animal science
fascicolo: 4, volume: 46, anno: 1996,
pagine: 430 - 433
SICI:
0023-6764(1996)46:4<430:EO2IAA>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
SYNTHETIC THROMBIN INHIBITORS; FENTANYL-DROPERIDOL DROPERIDOL; ADULT MALE-RATS; ANTITHROMBOTIC ACTION; RECOMBINANT HIRUDIN; KETAMINE-XYLAZINE; ANIMALS; DRUGS; MODEL; ANTICOAGULANT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
30
Recensione:
Indirizzi per estratti:
Citazione:
S.K. Stringer e B.E. Seligmann, "EFFECTS OF 2 INJECTABLE ANESTHETIC AGENTS ON COAGULATION ASSAYS IN THE RAT", Laboratory animal science, 46(4), 1996, pp. 430-433

Abstract

The rat is commonly used as an animal model to test the efficacy of new anticoagulant and antithrombotic drugs. Many of the protocols require the use of anesthetics for surgical procedures, Three common coagulation assays used to monitor the effects of new anticoagulant and antithrombotic drugs are thrombin time, activated partial thromboplastin time, and prothrombin time. We examined the effects of either urethane-or ketamine/xylazine-induced anesthesia on variables in the three coagulation assays with blood samples obtained from the rats before the induction of anesthesia, compared with samples obtained at 15 or 60 minafter anesthesia induction, Statistically significant differences were observed in the ketamine/xylazine group for thrombin time at 60 min (compared with control values) and in the urethane group for activatedpartial thromboplastin time at 60 min (compared with control values).in both instances a prolongation of times vas the effect seen. These results indicate that the choice of anesthetic affects the data in certain coagulation assays in the rat and must be taken into account whenone is planning studies and analyzing results.

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Documento generato il 28/11/20 alle ore 18:04:21