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Titolo:
EFFECTS OF THE BOWMAN-BIRK PROTEASE INHIBITOR ON SURVIVAL OF FIBROBLASTS AND CANCER-CELLS EXPOSED TO RADIATION AND CISPLATINUM
Autore:
KENNEDY CW; DONAHUE JJ; WAN XS;
Indirizzi:
UNIV PENN,DEPT RADIAT ONCOL,SCH MED,415 CURIE BLVD,530 CLIN RES BLDG PHILADELPHIA PA 19104 UNIV PENN,DEPT RADIAT ONCOL,SCH MED PHILADELPHIA PA 19104
Titolo Testata:
Nutrition and cancer
fascicolo: 2, volume: 26, anno: 1996,
pagine: 209 - 217
SICI:
0163-5581(1996)26:2<209:EOTBPI>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN POLYMORPHONUCLEAR LEUKOCYTES; LINE; CARCINOMA; INVITRO;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
19
Recensione:
Indirizzi per estratti:
Citazione:
C.W. Kennedy et al., "EFFECTS OF THE BOWMAN-BIRK PROTEASE INHIBITOR ON SURVIVAL OF FIBROBLASTS AND CANCER-CELLS EXPOSED TO RADIATION AND CISPLATINUM", Nutrition and cancer, 26(2), 1996, pp. 209-217

Abstract

The Bowman-Birk inhibitor (BBI) is a soybean-derived anticarcinogenicprotease inhibitor with anti-inflammatory activity. To assess the possibility of utilizing BBI for alleviating the side effects associated with lung cancer radiation and chemotherapy, we have determined the effects of BBI and a soybean concentrate enriched in BBI (known as BBIC)on radiation- and cis-platinum-induced cytotoxicity in A549 human lung cancer cells. The results demonstrated that neither BBI nor BBIC protected A549 cells from radiation- and cis-platinum-induced cytotoxicity. In fact, BBI and BBIC potentiated the cell-killing effects induced by cis-platinum alone, and BBIC treatment led to significantly enhanced cell killing by cis-platinum in combination with radiation treatmentin the lung carcinoma cells. BBI conferred a significant protective effect onto mouse fibroblasts (10T1/2 cells) treated with cis-platinum in combination with 6 Gy of X-ray irradiation. These results suggest that BBI and BBIC, when given to lung cancer patients, are unlikely to interfere with cancer treatment utilizing radiation and cis-platinum.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/10/20 alle ore 00:39:10