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Titolo:
P21(RAS) SUPPORTS THE SURVIVAL OF CHICK EMBRYONIC MOTOR-NEURONS
Autore:
WENG GH; MARKUS MA; MARKUS A; WINKLE A; BORASIO GD;
Indirizzi:
UNIV MUNICH,NEUROL KLIN,KLINIKUM GROSSHADERN D-81366 MUNICH GERMANY UNIV MUNICH,NEUROL KLIN,KLINIKUM GROSSHADERN D-81366 MUNICH GERMANY RUHR UNIV BOCHUM,ABT MOL NEUROBIOCHEM D-44780 BOCHUM GERMANY
Titolo Testata:
NeuroReport
fascicolo: 5, volume: 7, anno: 1996,
pagine: 1077 - 1081
SICI:
0959-4965(1996)7:5<1077:PSTSOC>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
NERVE GROWTH-FACTOR; NEUROTROPHIC FACTOR; TARGETED DISRUPTION; RAS; MOTONEURONS; EXPRESSION; GENE; PROTEINS; MUSCLE; P21;
Keywords:
NEURONAL SURVIVAL; NEUROTROPHIC FACTORS; SIGNAL TRANSDUCTION; TISSUE CULTURE; MOTOR NEURON DISEASE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
26
Recensione:
Indirizzi per estratti:
Citazione:
G.H. Weng et al., "P21(RAS) SUPPORTS THE SURVIVAL OF CHICK EMBRYONIC MOTOR-NEURONS", NeuroReport, 7(5), 1996, pp. 1077-1081

Abstract

VARIOUS trophic factors present in muscle extract can promote the survival of cultured Inotor neurones. However, little is known about the signal transduction pathways used in these cells. The proto-oncogene product p21(ras) has been shown to play an important role in proliferative and differentiative signalling pathways. We report here that cytoplasmic introduction of its oncogenic form, p21(ras)(G12V), fully supports the in vitro survival of chick embryonic motor neurones. The proto-oncogenic form of p21(ras) also showed a dose-dependent survival effect, while a C-terminally truncated counterpart of p21(ras)(G12V) was ineffective. These results suggest an involvement of p21(ras) in signaltransduction pathways leading to motor neurone survival and may be ofrelevance for the development of therapeutic strategies for motor neurone disease.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 00:07:41