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Titolo:
ORGANOPHOSPHATE MYOTOXICITY
Autore:
CAVALIERE MJ; CALORE EE; PEREZ NM; PUGA FR;
Indirizzi:
INST ADOLFO LUTZ REGISTRO,DIV PATOL,AV DR ARNALDO 355 BR-01246902 SAOPAULO BRAZIL INST EMILIO RIBAS,SECAO ANAT PATOL SAO PAULO BRAZIL INST BIL,SECAO TOXICOL & HIGIENE COMPARADA SAO PAULO BRAZIL
Titolo Testata:
Revista de Saude Publica
fascicolo: 3, volume: 30, anno: 1996,
pagine: 267 - 272
SICI:
0034-8910(1996)30:3<267:OM>2.0.ZU;2-F
Fonte:
ISI
Lingua:
POR
Soggetto:
MYOPATHY; MUSCLE; RAT; MECHANISMS; DIAPHRAGM; NECROSIS;
Keywords:
INSECTICIDES, ORGANOPHOSPHATE, TOXICOLOGY; MUSCLE FIBERS, PATHOLOGY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Citazioni:
19
Recensione:
Indirizzi per estratti:
Citazione:
M.J. Cavaliere et al., "ORGANOPHOSPHATE MYOTOXICITY", Revista de Saude Publica, 30(3), 1996, pp. 267-272

Abstract

Organophosphates comprise a group of chemical compounds extensively used in farming as insecticides, which cause accidental poisoning in animals and men and are also used in suicide attempts. The toxicity of these compounds is due especially to the cardiac and respiratory impairment in consequence of autonomic nervous system disorders. However it is known that some of these products induce a myopathy in experimentalanimals and humans. This myopathy is characterized by muscle cell degeneration, involving above all the respiratory muscles. Based on the fact that this involvement certainly enhances the respiratory impairment, this study offers an experimental method for routine evaluation of organophosphate myotoxicity, using a minimal and sufficient battery ofstains and histochemical reactions, for muscle necrosis quantification. For this purpose, albino vats (Wistar) treated with the organophosphate paraoxon, were used both with and without antidotes (atropine or pralidoxime). Muscle fiber necrosis in the diaphragm of the rats treated with paraoxon or paraoxon and atropine, that affected about 15% of the fibers in some areas, was detected In the group treated with paraoxon and pralidoxime, a minimal necrosis was seen, revealing a protective role of this later antidote during the development of myopathy.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/02/20 alle ore 20:14:46