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Titolo:
IN-VITRO DETERMINATION OF ANTIVIRAL ACTIVITY OF MSS209, A NEW AMPHOTERICIN-B DERIVATIVE, AGAINST PRIMARY ISOLATES OF HIV-1
Autore:
MAGIEROWSKAJUNG M; CEFAI D; MARRAKCHI H; CHIEZE F; AGUT H; HURAUX JM; SEMAN M;
Indirizzi:
HOP LA PITIE SALPETRIERE,CERVI,CNRS EP 57,VIROL LAB,83 BD HOP F-75651PARIS 13 FRANCE DANA FARBER CANC INST,DIV TUMOR IMMUNOL,IMMUNOL LAB BOSTON MA 02115 UNIV PARIS 07,LAB IMMUNODIFFERENCIAT F-75251 PARIS 05 FRANCE HOP LA PITIE SALPETRIERE,INSERM U313,DEPT MALAD INFECT PARASITAIRES TROP & SANTE PUBL F-75651 PARIS 13 FRANCE
Titolo Testata:
Research in virology
fascicolo: 5, volume: 147, anno: 1996,
pagine: 313 - 318
SICI:
0923-2516(1996)147:5<313:IDOAAO>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
MS-8209; ZIDOVUDINE;
Keywords:
HIV-1, AMPHOTERICIN B; DERIVATIVE MS8209, ANTIVIRAL ACTIVITY, PRIMARY ISOLATES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
7
Recensione:
Indirizzi per estratti:
Citazione:
M. Magierowskajung et al., "IN-VITRO DETERMINATION OF ANTIVIRAL ACTIVITY OF MSS209, A NEW AMPHOTERICIN-B DERIVATIVE, AGAINST PRIMARY ISOLATES OF HIV-1", Research in virology, 147(5), 1996, pp. 313-318

Abstract

MS8209. an amphotericin B derivative, was previously reported to be an inhibitor of HIV1 replication in vitro. In the present study, we determined the 50 and 90% in vitro inhibitory concentrations of MS8209 for 9 HIV1 isolates including both zidovudine-sensitive and zidovudine-resistant isolates and the reference strain Lai, using the peripheral blood mononuclear cell (PBMC) assay. We also evaluated the sensitivity of HIV1 replication to MS8209 during primary isolation from PBMCs. An inhibitory effect of MS8209 in PBMC infection was observed either whenthe drug was only present during the adsorption step or when the drugwas initially absent but maintained throughout the culture period; the combination of these two approaches provided the highest inhibition rate. These results indicate that MS8209 can inhibit the replication of HIV1 isolates in PBMCs and suggest that it mainly acts by blocking the virus entry into cells.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/11/20 alle ore 14:17:59