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OPAC HELP

Titolo:
APOLIPOPROTEIN-E AND ALZHEIMERS-DISEASE - STRENGTH OF ASSOCIATION IS RELATED TO AGE AT ONSET
Autore:
MURMAN DL; FOSTER NL; KILGORE SP; MCDONAGH CA; FINK JK;
Indirizzi:
UNIV MICHIGAN HOSP,DEPT NEUROL,TAUBMAN CTR 13240322,1500 E MED CTR DRANN ARBOR MI 48109 UNIV MICHIGAN,DEPT NEUROL ANN ARBOR MI 00000 DIV VET AFFAIRS ANN ARBOR MI 00000
Titolo Testata:
Dementia
fascicolo: 5, volume: 7, anno: 1996,
pagine: 251 - 255
SICI:
1013-7424(1996)7:5<251:AAA-SO>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
E ALLELE EPSILON-4; E POLYMORPHISM; TYPE-4 ALLELE; RISK FACTOR; FREQUENCY; DIAGNOSIS; GENE; CONFIRMATION;
Keywords:
APOLIPOPROTEIN E; ALZHEIMERS DISEASE; AGE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
32
Recensione:
Indirizzi per estratti:
Citazione:
D.L. Murman et al., "APOLIPOPROTEIN-E AND ALZHEIMERS-DISEASE - STRENGTH OF ASSOCIATION IS RELATED TO AGE AT ONSET", Dementia, 7(5), 1996, pp. 251-255

Abstract

Apolipoprotein E (apoE) epsilon 4 allele frequency among Alzheimer's disease (AD) patients is increased compared to control subjects and isinfluenced by the presence of other genetic factors and age at symptom onset. We examined the relationship between age at AD symptom onset and apoE by comparing the apoE epsilon 4 allele frequency of normal, elderly control subjects (n = 107) to that in AD patients (n = 123), divided into four age-at-onset periods. Additionally, the distribution of symptom onset ages of AD patients with and without apoE epsilon 4 alleles was determined. We observed increased apoE epsilon 4 allele frequencies between the AD onset ages of 55 and 75 years, but not at the extremes of onset ages (i.e. onset between 45 and 54 years of age and after age 75). Our data suggests that having an apoE epsilon 4 allele increases the likelihood that AD patients will develop symptoms in the middle range of onset ages. At the extremes of AD onset ages, non-apoEfactors, including other genetic factors and age, are more important determinants of risk of developing AD.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/07/20 alle ore 15:54:53