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Titolo:
CEREBRAL METABOLIC CHANGES IN ALZHEIMERS-DISEASE - NEUROBEHAVIORAL PATTERNS
Autore:
BLESA R; MOHR E; MILETICH RS; HILDEBRAND K; SAMPSON M; CHASE TN;
Indirizzi:
UNIV BARCELONA,SERV NEUROL,HOSP CLIN & PROV,VILLARROEL 170 E-08036 BARCELONA SPAIN UNIV OTTAWA,FAC MED NEUROL,OTTAWA CIVIC HOSP OTTAWA ON CANADA ELISABETH BRUYERE HLTH CTR OTTAWA ON CANADA DENT NEUROL INST BUFFALO NY 00000 NINCDS,EXPT THERAPEUT BRANCH,NIH BETHESDA MD 20892
Titolo Testata:
Dementia
fascicolo: 5, volume: 7, anno: 1996,
pagine: 239 - 245
SICI:
1013-7424(1996)7:5<239:CMCIA->2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON EMISSION TOMOGRAPHY; COMPUTED-TOMOGRAPHY; GLUCOSE-METABOLISM; SENILE DEMENTIA; HUMAN-BRAIN; PET; ABNORMALITIES; DIAGNOSIS; DISORDERS; CORTEX;
Keywords:
ALZHEIMERS DISEASE; CEREBRAL GLUCOSE METABOLISM; BEHAVIORAL NEUROANATOMY; POSITRON EMISSION TOMOGRAPHY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
51
Recensione:
Indirizzi per estratti:
Citazione:
R. Blesa et al., "CEREBRAL METABOLIC CHANGES IN ALZHEIMERS-DISEASE - NEUROBEHAVIORAL PATTERNS", Dementia, 7(5), 1996, pp. 239-245

Abstract

Regional cerebral glucose metabolism was surveyed in 37 Alzheimer's disease (AD) patients and 21 normal controls using positron emission tomography. Where possible, brain regions were specified according to their neurobehavioral function rather than as anatomically demarcated structures. Absolute metabolic values revealed significant differences (p < 0.05) between AD patients and controls for whole brain and the more superior supratentorial brain slices. Normalized values (region/brain stem) showed the most striking declines (p < 0.001) in the association cortex (heteromodal region -21%; unimodal region -19%) and the primary sensory-motor cortex (-13%), with motor, auditory, and visual areas more affected than somatosensory areas. Limbic and paralimbic systems were equally affected (-14%; -11%; p < 0.001). Thalamus, striatum, cerebellum and brain stem were minimally or not affected. Neurobehaviorally defined hypometabolic regions largely parallel affected areas noted in anatomic and previous metabolic studies, with the possible exception of metabolic deficits in the primary sensory-motor complex. Conceivably, brain areas unaffected morphologically by the pathophysiological processes of AD may become dysfunctional due to a disruption of connectivity between regions.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/09/20 alle ore 16:58:52