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Titolo:
STUDY OF PERCOLATION THRESHOLDS IN TERNARY TABLETS
Autore:
CARABALLO I; FERNANDEZAREVALO M; MILLAN M; RABASCO AM; LEUENBERGER H;
Indirizzi:
UNIV SEVILLE,FAC PHARM,DEPT PHARMACEUT TECHNOL,C PROF GARCIA GONZALEZS-N SEVILLE 41012 SPAIN UNIV BASEL,SCH PHARM CH-4051 BASEL SWITZERLAND
Titolo Testata:
International journal of pharmaceutics
fascicolo: 1-2, volume: 139, anno: 1996,
pagine: 177 - 186
SICI:
0378-5173(1996)139:1-2<177:SOPTIT>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
DOSAGE FORM DESIGN; FRACTAL GEOMETRY; SYSTEMS;
Keywords:
PERCOLATION THEORY; PERCOLATION THRESHOLD; TERNARY SYSTEMS; COMBINED PERCOLATION THRESHOLD;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
16
Recensione:
Indirizzi per estratti:
Citazione:
I. Caraballo et al., "STUDY OF PERCOLATION THRESHOLDS IN TERNARY TABLETS", International journal of pharmaceutics, 139(1-2), 1996, pp. 177-186

Abstract

One of the handicaps for the application of the principles of percolation theory in pharmaceutical systems is the fact that this theory hasbeen developed for binary systems. The aim of this work is to study for the first time the existence and behaviour of the percolation thresholds in ternary pharmaceutical tablets. For this purpose, mixtures containing three substances with very different hydrophilicity and water-solubility-KCl, polyvinylpyrrolidone cross-linked (PVP-CL) and Eudragit(R) RS-PM-were prepared and compressed. The bulk and tapped densities of the mixtures as well as the hardness and in-vitro release behaviour of the tablets have been studied. The KCI percolation threshold hasbeen estimated in the range 0.26-0.31 of total porosity. A range where PVP-CL percolates can be defined between LD and 30% v/v. This influences the hardness of the tablet. On the other hand, the existence of a'combined percolation threshold' of the sum of all the hydrophilic substances, i.e. KCl and PVP-CL, has been found at 35% v/v approximately. This fact is in agreement with previous results.

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Documento generato il 02/12/20 alle ore 07:02:42