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Titolo:
CENTRAL AND PERIPHERAL EFFECTS OF ASYMMETRIC DIMETHYLARGININE, AN ENDOGENOUS NITRIC-OXIDE SYNTHETASE INHIBITOR
Autore:
JIN JS; DALECY LG;
Indirizzi:
UNIV MICHIGAN,SCH MED,DEPT PHYSIOL,7799 MED SCI BLDG 2,1301 E CATHERINE ST ANN ARBOR MI 48109 UNIV MICHIGAN,SCH MED,DEPT PHYSIOL ANN ARBOR MI 48109 UNIV MICHIGAN,SCH MED,DEPT SURG ANN ARBOR MI 48109
Titolo Testata:
Journal of cardiovascular pharmacology
fascicolo: 3, volume: 28, anno: 1996,
pagine: 439 - 446
SICI:
0160-2446(1996)28:3<439:CAPEOA>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
RELAXING FACTOR; SMOOTH-MUSCLE; RATS; NG,NG-DIMETHYLARGININE; HYPERTENSION; RELAXATION; BLOCKADE; RABBITS; ENZYME;
Keywords:
NITRIC OXIDE; NITRIC OXIDE SYNTHETASE; L-ARGININE; INTRACEREBROVENTRICULAR; VASCULAR SMOOTH MUSCLE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
28
Recensione:
Indirizzi per estratti:
Citazione:
J.S. Jin e L.G. Dalecy, "CENTRAL AND PERIPHERAL EFFECTS OF ASYMMETRIC DIMETHYLARGININE, AN ENDOGENOUS NITRIC-OXIDE SYNTHETASE INHIBITOR", Journal of cardiovascular pharmacology, 28(3), 1996, pp. 439-446

Abstract

We tested the hypothesis that the endogenous nitric oxide synthetase (NOS) inhibitor, asymmetric dimethylarginine (ADMA), regulates cardiovascular function by central mechanisms. In in vivo studies, rats received intracerebroventricular (i.c.v.) injection of isotonic saline, ADMA (1 mg), 1-arginine (3 mg), and N-omega-nitro-1-arginine methylester (1-NAME, 1 mg). Baroreflex function was then assessed by intravenous (i.v.) injection of phenylephrine. Central application of exogenous NOSinhibitor, 1-NAME, increased mean arterial blood pressure and decreased heart rate. However, application of the endogenous NOS inhibitor, ADMA, decreased mean arterial blood pressure and heart rate simultaneously (-39 +/- 6 mm Hg and -50 +/- 8 beats/min, respectively). Both 1-NAME (i.c.v.) and ADMA (i.c.v.) significantly inhibited the baroreflex function, indicating a regulatory role of central nitric oxide in controlling baroreflex function. In contrast to the central effect, intravenous injection of ADMA caused dose-dependent increases in mean arterial blood pressure that could be blocked by 1-NAME pretreatment. In vitro studies using aortic rings demonstrated that ADMA (10(-4) M) significantly increased the concentration of acetylcholine for the threshold response (EC15) and half-maximal response (EC50). This indicates that ADMA inhibits the constitutive isoform of NOS in the endothelium. ADMAmay have functional importance in regulating cardiovascular function by mechanisms in addition to the inhibition of nitric oxide synthesis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/04/20 alle ore 03:53:09