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Titolo:
FACTORS AFFECTING THE ROLE OF THE SPINDLE DURING EARLY RESPONSE OF MOUSE OOCYTES TO ETHANOL STIMULATION
Autore:
RYBOUCHKIN A; DOZORTSEV D; DESUTTER P; DHONT M;
Indirizzi:
STATE UNIV GHENT HOSP,DEPT OBSTET & GYNAECOL,DE PINTELAAN 185 B-9000 GHENT BELGIUM
Titolo Testata:
The Journal of experimental zoology
fascicolo: 6, volume: 275, anno: 1996,
pagine: 469 - 475
SICI:
0022-104X(1996)275:6<469:FATROT>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
METAPHASE ARREST; CALCIUM; ACTIVATION; CYCLE; EGGS; FERTILIZATION; TRANSITION; INTERPHASE; INCREASES; CAPACITY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
21
Recensione:
Indirizzi per estratti:
Citazione:
A. Rybouchkin et al., "FACTORS AFFECTING THE ROLE OF THE SPINDLE DURING EARLY RESPONSE OF MOUSE OOCYTES TO ETHANOL STIMULATION", The Journal of experimental zoology, 275(6), 1996, pp. 469-475

Abstract

Winston et al. ([1995] J. Cell Sci., 108:143-151) have shown recentlythat short (6 min) exposure of spindle intact oocytes from Swiss miceto 8% ethanol induced activation of most oocytes, while disruption ofthe spindles in these oocytes by nocodazole, before and during ethanol exposure, completely inhibited oocyte activation. We compared the activation rates (ARs) of nocodazole-treated and intact oocytes recovered from SJL and B6D2 F1 hybrid mice under the same experimental conditions. The difference between the ARs of nocodazole-treated and intact SU oocytes was about the same as reported for Swiss oocytes (2% vs. 82%, respectively). In contrast, this difference was minor for B6D2 oocytes (87% vs. 100%, respectively). Moreover, 41% of these oocytes underwent activation when the spindle was absent, not only before and during, but also 2 h after ethanol exposure. Shortened exposure (2 min) of B6D2 oocytes to ethanol, however, increased the difference in the ARs of nocodazole-treated and intact oocytes (18% vs. 67%, respectively). We conclude that at least two parameters affect the necessity of the presence of the spindle during ethanol exposure for the activation of mouse oocytes. They are the genotype of the oocytes and the duration of exposure to ethanol. Under one set of these parameters the presence ofthe spindle is absolutely necessary, while under the other the appearance of the spindle a few hours after ethanol exposure is sufficient to allow the activation of some oocytes. (C) 1996 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 09:55:43