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Titolo:
THIAZOLIDINEDIONES REPRESS OB GENE-EXPRESSION IN RODENTS VIA ACTIVATION OF PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR-GAMMA
Autore:
DEVOS P; LEFEBVRE AM; MILLER SG; GUERREMILLO M; WONG K; SALADIN R; HAMANN LG; STAELS B; BRIGGS MR; AUWERX J;
Indirizzi:
LIGAND PHARMACEUT INC,9393 TOWNE CTR DR SAN DIEGO CA 92121 LIGAND PHARMACEUT INC SAN DIEGO CA 92121 INST PASTEUR,INSERM U325 F-59019 LILLE FRANCE INST PASTEUR,DEPT ATHEROSCLEROSE F-59019 LILLE FRANCE INST BIOMED CORDELIERS,INSERM U177 F-75006 PARIS FRANCE
Titolo Testata:
The Journal of clinical investigation
fascicolo: 4, volume: 98, anno: 1996,
pagine: 1004 - 1009
SICI:
0021-9738(1996)98:4<1004:TROGIR>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
ENHANCES ADIPOCYTE DIFFERENTIATION; INSULIN-SENSITIZING AGENT; WHITE ADIPOSE-TISSUE; APOLIPOPROTEIN C-III; MOUSE OBESE GENE; MESSENGER-RNA; BODY-WEIGHT; FOOD-INTAKE; PROMOTER ACTIVITY; RAT ADIPOCYTES;
Keywords:
OBESITY; ANTIDIABETIC; ADIPOCYTE; ADIPOSE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
61
Recensione:
Indirizzi per estratti:
Citazione:
P. Devos et al., "THIAZOLIDINEDIONES REPRESS OB GENE-EXPRESSION IN RODENTS VIA ACTIVATION OF PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR-GAMMA", The Journal of clinical investigation, 98(4), 1996, pp. 1004-1009

Abstract

The ob gene product, leptin, is a signaling factor regulating body weight and energy balance, ob gene expression in rodents is increased inobesity and is regulated by feeding patterns and hormones, such as insulin and glucocorticoids, In humans with gross obesity, ob mRNA levels are higher, but other modulators of human ob expression are unknown,In view of the importance of peroxisome proliferator-activated receptor gamma (PPAR gamma) in adipocyte differentiation, we analyzed whether ob gene expression is subject to regulation by factors activating PPARs, Treatment of rats with the PPAR alpha activator fenofibrate did not change adipose tissue and body weight and had no significant effecton ob mRNA levels, However, administration of the thiazolidinedione BRL49653, a PPAR gamma ligand, increased food intake and adipose tissueweight while reducing ob mRNA levels in rats in a dose-dependent manner, The inhibitory action of the thiazolidinedione BRL49653 on ob mRNAlevels was also observed in vitro, Thiazolidinediones reduced the expression of the human ob promoter in primary adipocytes, however, in undifferentiated 3T3-L1 preadipocytes lacking endogenous PPAR gamma, cotransfection of PPAR gamma was required to observe the decrease, In conclusion, these data suggest that PPAR gamma activators reduce ob mRNA levels through an effect of PPAR gamma on the ob promoter.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 19:30:31