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Titolo:
SUPEROXIDE-DISMUTASE ACTIVITY IN CEREBROSPINAL-FLUID AND ITS RELATIONTO COMPRESSION OF THE LUMBOSACRAL NERVE ROOT
Autore:
TAMADA T; INOUE H; MORI A;
Indirizzi:
OKAYAMA UNIV,SCH MED,DEPT ORTHOPAED SURG,2-5-1 SHIKATA CHO OKAYAMA 700 JAPAN OKAYAMA UNIV,SCH MED,INST CELLULAR & MOL MED,DEPT NEUROSCI OKAYAMA 700 JAPAN
Titolo Testata:
Acta medica Okayama
fascicolo: 4, volume: 50, anno: 1996,
pagine: 197 - 201
SICI:
0386-300X(1996)50:4<197:SAICAI>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
PORCINE CAUDA-EQUINA; INTESTINAL ISCHEMIA; GRADED COMPRESSION; BLOOD-FLOW; HERNIATION; SCIATICA; RADICALS; INJURY;
Keywords:
SUPEROXIDE DISMUTASE (SOD); CEREBROSPINAL FLUID (CSF); NERVE ROOT COMPRESSION; INFLAMMATION; FREE RADICALS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
30
Recensione:
Indirizzi per estratti:
Citazione:
T. Tamada et al., "SUPEROXIDE-DISMUTASE ACTIVITY IN CEREBROSPINAL-FLUID AND ITS RELATIONTO COMPRESSION OF THE LUMBOSACRAL NERVE ROOT", Acta medica Okayama, 50(4), 1996, pp. 197-201

Abstract

In the pathophysiology of lumbosacral radiculopathy, inflammation of the nerve root is of critical importance. Additionally, free radicals have been shown to be associated with some inflammatory process. This study was designed to investigate whether free radicals participate inthe pathophysiology of nerve root involvement. We measured superoxidedismutase (SOD) activity in cerebrospinal fluid (CSF) of 31 patients with unilateral lumbosacral radiculopathy caused by a herniated disc using electron spin resonance (ESR) spectrometry. Then SOD activity wascompared with the type of nerve root compression as seen on preoperative myelography. SOD activity in the normal control group was 7U/ml, while that in the hernia group remarkably decreased. The concentration gradient of SOD activity was different between central herniation and centrolateral herniation. Our findings indicate that free radicals aregenerated after nerve root compression. Under severe deficiency of SOD activity in CSF, serum SOD penetrates into CSF after further compression. In addition, SOD in CSF may play an important role in protectingagainst nerve root involvement.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 12:18:19