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Titolo:
CALCIUM-TRANSPORT AND THE LOCALIZATION OF CALBINDIN-D-9K IN THE RUMINANT PLACENTA DURING THE 2ND HALF OF PREGNANCY
Autore:
WOODING FBP; MORGAN G; JONES GV; CARE AD;
Indirizzi:
BABRAHAM INST CAMBRIDGE CB2 4AT ENGLAND UNIV WALES,INST BIOL SCI ABERYSTWYTH SY23 3DD DYFED WALES
Titolo Testata:
Cell and tissue research
fascicolo: 3, volume: 285, anno: 1996,
pagine: 477 - 489
SICI:
0302-766X(1996)285:3<477:CATLOC>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
HORMONE-RELATED PROTEIN; BINDING PROTEIN; IMMUNOHISTOCHEMICAL LOCALIZATION; CHICK INTESTINE; UTERUS; SHEEP; PROGESTERONE; ACCUMULATION; STIMULATION; EXPRESSION;
Keywords:
PLACENTA; INTERPLACENTOMAL EPITHELIUM; CALBINDIN-D-9K LOCALIZATION; CALCIUM TRANSPORT; SHEEP (CLUN, WELSH MOUNTAIN); COW (FRIESIAN); GOAT (SAANEN);
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
31
Recensione:
Indirizzi per estratti:
Citazione:
F.B.P. Wooding et al., "CALCIUM-TRANSPORT AND THE LOCALIZATION OF CALBINDIN-D-9K IN THE RUMINANT PLACENTA DURING THE 2ND HALF OF PREGNANCY", Cell and tissue research, 285(3), 1996, pp. 477-489

Abstract

In late pregnancy the sheep fetus requires 3 g of calcium per day, all of which must be transported across the trophoblast epithelium of the placenta. Such high levels of calcium transport across other epithelia are normally associated with the presence of calbindin-D-9 or (-28k). Our immunocytochemical results show that ovine, bovine and caprine interplacentomal trophoblast have high levels of calbindin-D-9k, abouteight to ten times more than in the placentomal region. The protein is detectable only in the uninucleate trophoblast cells in sheep and goat, the frequent binucleate cells show none. The calbindin-D-9k is also present in the maternal glandular epithelium but not the surface epithelium of the uterus. The cellular distribution of the calbindin-D-9kimmunoreactivity suggests a soluble protein homogenously distributed through cytosol and nucleoplasm but absent from all organelles and intercellular spaces. In contrast, the uterine milk protein(s) are localised in Golgi cisternae and secretory vesicles in gland cells and in apical small endocytic vesicles and lysosomes in the uninucleate trophectodermal cells. The distribution of calbindin-D-9k supports the concept that it mediates the high calcium flux by facilitated diffusion and not via any vesicular, membrane-bounded system.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/09/20 alle ore 09:24:14