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Titolo:
SINGLE-PHOTON EMISSION COMPUTED-TOMOGRAPHY WITH IODOAMPHETAMINE-123 AND NEUROPSYCHOLOGICAL STUDIES IN LONG-TERM ABSTINENT ALCOHOLICS
Autore:
DUPONT RM; ROURKE SB; GRANT I; LEHR PP; REED RJ; CHALLAKERE K; LAMOUREUX G; HALPERN S;
Indirizzi:
UNIV TORONTO,WELLESLEY HOSP,DEPT PSYCHIAT,TURNER WING,ROOM 702,160 WELLESLEY ST E TORONTO ON M4Y 1J3 CANADA UNIV TORONTO,WELLESLEY HOSP,DEPT PSYCHIAT TORONTO ON M4Y 1J3 CANADA VET ADM MED CTR,PSYCHIAT SERV SAN DIEGO CA 92161 UNIV CALIF SAN DIEGO,DEPT PSYCHIAT LA JOLLA CA 92093 UNIV SHERBROOKE,DEPT NUCL MED SHERBROOKE PQ J1H 5N4 CANADA UNIV CALIF SAN DIEGO,DEPT RADIOL SAN DIEGO CA 00000 VET ADM MED CTR,NUCL MED SERV SAN DIEGO CA 92161
Titolo Testata:
PSYCHIATRY RESEARCH-NEUROIMAGING
fascicolo: 2, volume: 67, anno: 1996,
pagine: 99 - 111
SICI:
0925-4927(1996)67:2<99:SECWIA>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
CEREBRAL BLOOD-FLOW; WERNICKE-KORSAKOFF SYNDROME; BRAIN GLUCOSE-METABOLISM; RISK-FACTORS; FRONTAL HYPOMETABOLISM; FOLLOW-UP; LATE 30S; RECOVERY; CAFFEINE; SMOKING;
Keywords:
CEREBRAL BLOOD FLOW; RAVENS PROGRESSIVE MATRICES; ALCOHOL DEPENDENCE; SMOKING;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
72
Recensione:
Indirizzi per estratti:
Citazione:
R.M. Dupont et al., "SINGLE-PHOTON EMISSION COMPUTED-TOMOGRAPHY WITH IODOAMPHETAMINE-123 AND NEUROPSYCHOLOGICAL STUDIES IN LONG-TERM ABSTINENT ALCOHOLICS", PSYCHIATRY RESEARCH-NEUROIMAGING, 67(2), 1996, pp. 99-111

Abstract

Ten long-term abstinent alcoholics (mean abstinence = 7.7 years) werecompared with 13 recently detoxified substance-dependent inpatients (mean abstinence = 25 days) and 8 nonalcoholic control subjects on global and regional measures of cortical cerebral blood flow (CBF), and onneuropsychological measures. CBF was assessed using (123)iodoamphetamine (IMP) single photon emission computed tomography (SPECT) under conditions of behavioral challenge (Raven's Progressive Matrices), CBF and neuropsychological test performance were worse in the recently detoxified inpatients. Of greater interest, there was a dissociation in thelong-term abstinent group, which, while neuropsychologically indistinguishable from controls, showed significantly decreased mean cortical IMP uptake. We conclude that there may be persistant physiologic abnormalities in long-term abstinent alcoholics who have achieved full behavioral recovery, Smoking on the day of SPECT scanning was also identified to be a significant confound to understanding CBF changes in alcoholism.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 06:28:31